Prenatal adverse life events increase the risk for atopic diseases in children, which is enhanced in the absence of a maternal atopic predisposition

Slides:

Advertisements

Similar presentations

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

Advertisements

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Prevalence of atopic dermatitis in infants by domestic water hardness and season of birth: Cohort study Kristiane A. Engebretsen, MD, Peter Bager, MSc,

Staphylococcus aureus sensitization and allergic disease in early childhood: Population- based birth cohort study Aida Semic-Jusufagic, MD, Claus Bachert,

Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O

Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children Woo Kyung Kim, MD, PhD, Ji-Won Kwon,

Pharmacologic rationale for treating allergic and nonallergic rhinitis

Asthma exacerbations: Origin, effect, and prevention

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Ann-Marie M. Schoos, MD, PhD, Jacob D

Sara J. Brown, MRCP, Caroline L

Is 9 more than 2 also in allergic airway inflammation?

Probiotics during the first 7 years of life: A cumulative risk reduction of eczema in a randomized, placebo-controlled trial Marko Kalliomäki, MD, PhD,

Children with allergic and nonallergic rhinitis have a similar risk of asthma Bo Lund Krogsgaard Chawes, MD, Klaus Bønnelykke, MD, PhD, Eskil Kreiner-Møller,

Meta-analysis of filaggrin polymorphisms in eczema and asthma: Robust risk factors in atopic disease Elke Rodríguez, MSc, Hansjörg Baurecht, MSc, Esther.

Prevalence of atopic dermatitis in infants by domestic water hardness and season of birth: Cohort study Kristiane A. Engebretsen, MD, Peter Bager, MSc,

Mothers' anxiety during pregnancy is associated with asthma in their children Hannah Cookson, MB, ChB, Raquel Granell, PhD, Carol Joinson, PhD, Yoav Ben-Shlomo,

Rising prevalence of asthma is sex-specific in a US farming population

BCG vaccination and allergy: A systematic review and meta-analysis

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Katherine A. Vierk, MPH, Kathleen M. Koehler, PhD, MPH, Sara B

Clinical studies of the DP1 antagonist laropiprant in asthma and allergic rhinitis George Philip, MD, Janet van Adelsberg, MD, Thomas Loeys, PhD, Nancy.

Furry pets modulate gut microbiota composition in infants at risk for allergic disease Merja Nermes, MD, PhD, Akihito Endo, PhD, Jasmin Aarnio, BM, Seppo.

Peter M. Wolfgram, MD, David B. Allen, MD

Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O

An age-dependent association of mannose-binding lectin-2 genetic variants on HIV-1– related disease in children Kumud K. Singh, PhD, Alexis Lieser, MD,

IL-5 T-cell responses to house dust mite are associated with the development of allergen-specific IgE responses and asthma in the first 5 years of life

Cats and dogs and the risk of atopy in childhood and adulthood

The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: HealthNuts age 4-year follow-up Rachel L.

Intranasal triamcinolone use during pregnancy and the risk of adverse pregnancy outcomes Anick Bérard, MSc, PhD, Odile Sheehy, MSc, Marie-Laure Kurzinger,

Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children Woo Kyung Kim, MD, PhD, Ji-Won Kwon,

Low diversity of the gut microbiota in infants with atopic eczema

Staphylococcus aureus colonization is associated with wheeze and asthma among US children and young adults Meghan F. Davis, PhD, Roger D. Peng, PhD,

What are the best outcome measurements for atopic eczema

Is eczema really on the increase worldwide?

Atopic dermatitis: A practice parameter update 2012

Reduced risk of peanut sensitization following exposure through breast-feeding and early peanut introduction Tracy J. Pitt, MD, Allan B. Becker, MD,

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

Karen C. Dannemiller, PhD, Janneane F. Gent, PhD, Brian P

Daphne Koinis-Mitchell, PhD, Timothy Craig, DO, Cynthia A

A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,

Claus Bachert, MD, PhD, Cezmi A. Akdis, MD

What is an “eosinophilic phenotype” of asthma?

Endotyping early childhood asthma by quantitative symptom assessment

Polyunsaturated fatty acids in plasma at 8 years and subsequent allergic disease Jessica Magnusson, PhD, Sandra Ekström, MSc, Inger Kull, PhD, Niclas.

Rachel Enriquez, RN, PhD, Marie R. Griffin, MD, MPH, Kecia N

Autophagy: Nobel Prize 2016 and allergy and asthma research

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Geographic variability in childhood asthma prevalence in Chicago

Mary F. Linehan, PhD, Timothy L. Frank, MD, Michelle L

Household peanut consumption as a risk factor for the development of peanut allergy Adam T. Fox, FRCPCH, Peter Sasieni, PhD, George du Toit, FRCPCH, Huma.

Risk of oral food challenges

Susan A. Rudders, MD, Sarah A. Arias, PhD, Carlos A

Day-care attendance, position in sibship, and early childhood wheezing: A population- based birth cohort study Nicolaos C. Nicolaou, MD, MPhil, Angela.

Frederika A. van Nimwegen, MSc, John Penders, PhD, Ellen E

The relationship between vaccine refusal and self-report of atopic disease in children Rachel Enriquez, PhD, Whitney Addington, MD, Faith Davis, PhD,

Atopic endotype in childhood

The Editors' Choice Journal of Allergy and Clinical Immunology

Increased food diversity in the first year of life is inversely associated with allergic diseases Caroline Roduit, MD, MPH, Remo Frei, PhD, Martin Depner,

Personal and parental nativity as risk factors for food sensitization

Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization.

Environmental factors and eosinophilic esophagitis

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

Advances in pediatric asthma in 2007

Negative affect, medication adherence, and asthma control in children

Allergen-specific IgG antibody levels modify the relationship between allergen-specific IgE and wheezing in childhood Adnan Custovic, MD, PhD, Lars Soderstrom,

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

Presentation transcript:

Prenatal adverse life events increase the risk for atopic diseases in children, which is enhanced in the absence of a maternal atopic predisposition Isabel R.V. Hartwig, MSc, Peter D. Sly, MD, Louis A. Schmidt, PhD, Ryan J. van Lieshout, MD, PhD, John Bienenstock, MD, Patrick G. Holt, PhD, Petra C. Arck, MD Journal of Allergy and Clinical Immunology Volume 134, Issue 1, Pages 160-169.e7 (July 2014) DOI: 10.1016/j.jaci.2014.01.033 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A differential diagnosis of the atopic diseases asthma, rhinitis, and eczema in the study population and frequency of nonatopic and atopic asthma among children in response to prenatal life events. A, Prevalence of asthma in children at age 6 years and age 14 years; the percentages relate to the population with or without a diagnosis at age 6 years. B, The frequency of children with atopic or nonatopic asthma at age 14 years, depicted in response to number (n) of prenatal life events that occurred between gestational weeks 18 and 34. *Indicates significant adjusted OR of 1.52 (95% CI: 1.14-3.25) for atopic asthma in children of mothers who had 1 life event compared with those with no life events. These results were derived from a post hoc multinomial regression analysis adjusted for confounders. The numbers below the life event categories show the total number of children with asthma (atopic and nonatopic) per total number of children within category. C, Prevalence of allergic rhinitis in children at age 6 years and age 14 years; the percentages relate to the population with or without diagnosis at age 6 years. D, The prevalence of eczema in children at age 6 years and age 14 years. The percentages relate to the population with or without a diagnosis at age 6 years. Journal of Allergy and Clinical Immunology 2014 134, 160-169.e7DOI: (10.1016/j.jaci.2014.01.033) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Number of children with 1 or multiple atopic diseases at age 6 years (A) and 14 years (B). Percentages relate to the parent population. Children with 3 atopic diseases, with asthma, allergic rhinitis, and eczema. Journal of Allergy and Clinical Immunology 2014 134, 160-169.e7DOI: (10.1016/j.jaci.2014.01.033) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions