Antimüllerian hormone levels decrease in women using combined contraception independently of administration route Sanna Kallio, M.D., Johanna Puurunen,

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Presentation transcript:

Antimüllerian hormone levels decrease in women using combined contraception independently of administration route Sanna Kallio, M.D., Johanna Puurunen, M.D., Aimo Ruokonen, M.D., Ph.D., Tommi Vaskivuo, M.D., Ph.D., Terhi Piltonen, M.D., Ph.D., Juha S. Tapanainen, M.D., Ph.D. Fertility and Sterility Volume 99, Issue 5, Pages 1305-1310 (April 2013) DOI: 10.1016/j.fertnstert.2012.11.034 Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Serum antimüllerian hormone (AMH) levels at baseline and after 5 and 9 weeks of administration of combined contraceptives by three different routes (oral [Pill], transdermal [Patch], and vaginal [Ring]). *P=.001 vs. baseline. Fertility and Sterility 2013 99, 1305-1310DOI: (10.1016/j.fertnstert.2012.11.034) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Serum inhibin B levels at baseline and after 5 and 9 weeks of administration of combined contraceptives by three different routes (oral [Pill], transdermal [Patch], and vaginal [Ring]). *P<.001 vs. baseline. Fertility and Sterility 2013 99, 1305-1310DOI: (10.1016/j.fertnstert.2012.11.034) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Effect of FSH on follicular growth and antimüllerian hormone (AMH) secretion in the ovary without (A) and during the use of combined contraception (B). Combined contraceptives reduce the effect of FSH and thus inhibit the growth of follicles, mainly in the antral stage. Reduced granulosa cell (GC) mass of the follicles results in a significant decrease in AMH secretion, mainly in antral follicles, but perhaps to some extent also in follicles at preceding stages. Fertility and Sterility 2013 99, 1305-1310DOI: (10.1016/j.fertnstert.2012.11.034) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions