Figure 5 IM amplification loop of type 1 IFN-inducible gene expression

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Figure 5 IM amplification loop of type 1 IFN-inducible gene expression IM amplification loop of type 1 IFN-inducible gene expression Skeletal muscle in DM shows perifascicular atrophy and loss of capillaries. Both myofibers and capillary endothelial cells express type 1 IFN-inducible gene transcripts. In addition, B cells within the endo- and perimysial space express type 1 IFN-inducible gene transcripts, e.g., MxA. Tubuloreticular inclusions within endothelial cells and B cells can be considered downstream markers of type 1 IFN signaling, illustrating specific damage of these structures. The reciprocal effects of IFNs on the perifascicular fibers, capillaries, and B cells may, once activated, feed an amplification loop that enhances adverse pathomechanisms in DM. DM = dermatomyositis; IFN = interferon; MxA = myxovirus resistance gene A. Josefine Radke et al. Neurol Neuroimmunol Neuroinflamm 2018;5:e451 Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.