More Chores for TOR: De Novo Ceramide Synthesis

Slides:

Advertisements

Similar presentations

Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E Yumi Kim, Andrew J. Holland, Weijie Lan, Don W. Cleveland.

Advertisements

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

Common Sense about Taste: From Mammals to Insects David A. Yarmolinsky, Charles S. Zuker, Nicholas J.P. Ryba Cell Volume 139, Issue 2, Pages (October.

Genome-wide Single-Cell Analysis of Recombination Activity and De Novo Mutation Rates in Human Sperm Jianbin Wang, H. Christina Fan, Barry Behr, Stephen.

Cost of Unneeded Proteins in E. coli Is Reduced after Several Generations in Exponential Growth Irit Shachrai, Alon Zaslaver, Uri Alon, Erez Dekel Molecular.

Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase Simon A. Hawley, David A. Pan, Kirsty J.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Cancer Metabolism Cell Volume 148, Issue 3, (February 2012) DOI: /j.cell Copyright © 2012 Terms and Conditions Terms and Conditions.

Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis Wing-Hang Tong, Tracey A. Rouault Cell.

ER-to-Plasma Membrane Tethering Proteins Regulate Cell Signaling and ER Morphology Andrew G. Manford, Christopher J. Stefan, Helen L. Yuan, Jason A. MacGurn,

Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation Joseph Tcherkezian, Perry A. Brittis, Franziska Thomas,

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.

Lipin-1 Regulates Autophagy Clearance and Intersects with Statin Drug Effects in Skeletal Muscle Peixiang Zhang, M. Anthony Verity, Karen Reue Cell Metabolism.

CDK Inhibitors: Cell Cycle Regulators and Beyond Arnaud Besson, Steven F. Dowdy, James M. Roberts Developmental Cell Volume 14, Issue 2, Pages

Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:

Oxygen Sensors at the Crossroad of Metabolism Julián Aragonés, Peter Fraisl, Myriam Baes, Peter Carmeliet Cell Metabolism Volume 9, Issue 1, Pages

Dual regulation of the LDL receptor—Some clarity and new questions

The ART of Lowering Ceramides

Volume 14, Issue 2, Pages (August 2011)

Jochen G. Schneider, Joseph H. Nadeau Cell Metabolism

Novel SIRT1 Mutation Linked to Autoimmune Diabetes in Humans

AMPK-Dependent Phosphorylation of ULK1 Induces Autophagy

Pancreatic β cells: Responding to the matrix

Volume 13, Issue 1, Pages 5-6 (January 2011)

Sphingolipid Signaling in Metabolic Disorders

Serotonin and the Orchestration of Energy Balance

mTORC1 Signaling Aids in CADalyzing Pyrimidine Biosynthesis

Calcium Signals Control Wnt-Dependent Dendrite Growth

Cellular Fatty Acid Metabolism and Cancer

A Radical Role for p38 MAPK in Tumor Initiation

Regulation of Ceramide Biosynthesis by TOR Complex 2

Identification of TOR Signaling Complexes

Volume 13, Issue 1, Pages 5-6 (January 2011)

Metabolic Networks of Longevity

Chapter 65 - The Hormonal Regulation of Calcium Metabolism

Independent Control of Aging and Axon Regeneration

The CAMplexities of Central Ghrelin

Treating Obesity? It's in the Bag!

Autophagy: A Sweet Process in Diabetes

Volume 58, Issue 1, Pages (July 2000)

Autophagy: A Potential Link between Obesity and Insulin Resistance

Beyond Energy Homeostasis: the Expanding Role of AMP-Activated Protein Kinase in Regulating Metabolism David Carling, Benoit Viollet Cell Metabolism

Modifying Mitochondrial tRNAs: Delivering What the Cell Needs

Volume 11, Issue 6, Pages (June 2010)

Powering Reprogramming with Vitamin C

Modulating Cholesterol Homeostasis to Build a Better T Cell

Proteins in Plant Brassinosteroid Signaling

Keith D. Baker, Carl S. Thummel Cell Metabolism

Iron Sensing as a Partnership: HFE and Transferrin Receptor 2

Adiponectin Receptor Signaling: A New Layer to the Current Model

The Yeast Saccharomyces cerevisiae: A Versatile Model System for the Identification and Characterization of Bacterial Virulence Proteins Keri A. Siggers,

Separating the Good and Evil of Cardiac Growth by CIB1 and Calcineurin

Volume 14, Issue 2, Pages (August 2011)

Adipose Dendritic Cells Come Out of Hiding

Protein nutrition as therapy for a genetic disorder of bone?

TOR Regulation: Sorting out the Answers

Adiponectin: Starving for Attention

TOR and Aging: Less Is More

Paradoxical Effects of Sphingosine-1-Phosphate

Christina L. Rosenberger, Jie Chen Molecular Cell

Macrophage Metabolism Shapes Angiogenesis in Tumors

Lysosomal Rag-ulation of mTOR Complex 1 Activity

Volume 24, Issue 1, Pages 7-8 (July 2016)

Of Mice and Men: Not ExAKTly the Same?

Tipping the Energy Balance toward Longevity

AMPK and p53 help cells through lean times

Presentation transcript:

More Chores for TOR: De Novo Ceramide Synthesis Robert C. Dickson Cell Metabolism Volume 7, Issue 2, Pages 99-100 (February 2008) DOI: 10.1016/j.cmet.2008.01.002 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 De Novo Ceramide and Sphingolipid Synthesis Is Regulated by TORC2 in Yeast Initial steps in sphingolipid synthesis up through formation of dihydroceramide are fairly well conserved in eukaryotes including the baker's yeast Saccharomyces cerevisiae and mammals. TORC2 in yeast senses growth signals and activates the protein kinase Ypk2, which then activates ceramide synthase. The Ca2+/calmodulin-regulated protein phosphatase calcineurin opposes the TORC2-Ypk2 pathway to downregulate ceramide synthase activity. Cell Metabolism 2008 7, 99-100DOI: (10.1016/j.cmet.2008.01.002) Copyright © 2008 Elsevier Inc. Terms and Conditions