Volume 5, Issue 1, Pages 1-2 (October 2013)

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Volume 5, Issue 1, Pages 1-2 (October 2013) Long Noncoding RNAs in Development: Solidifying the Lncs to Hox Gene Regulation Jeremy S. Dasen Cell Reports Volume 5, Issue 1, Pages 1-2 (October 2013) DOI: 10.1016/j.celrep.2013.09.033 Copyright © 2013 The Authors Terms and Conditions

Figure 1 Regulatory Interactions Between LncRNAs and Hox Genes (A) LncRNAs implicated in the regulation of Hox gene expression are indicated in purple. Hox loci also produce many additional lncRNAs, but for simplicity, these are not shown. (B) Hotair represses posterior HoxD genes in trans through the recruitment of PRC2 and LSD complexes. In Hotair mutants, HoxD are derepressed, and mice display skeletal deformalities. (C) The locus that produces Hog and Tog physically associates in cis with genes active in the HoxD cluster. These HoxD genes are expressed in the caecum (indicated in green), where Hog is specifically expressed. Other enhancer contacts are not shown. Cell Reports 2013 5, 1-2DOI: (10.1016/j.celrep.2013.09.033) Copyright © 2013 The Authors Terms and Conditions