In Silico Derivation of HLA-Specific Alloreactivity Potential from Whole Exome Sequencing of Stem Cell Transplant Donor-Recipient Pairs Maximilian Jameson-Lee,

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In Silico Derivation of HLA-Specific Alloreactivity Potential from Whole Exome Sequencing of Stem Cell Transplant Donor-Recipient Pairs Maximilian Jameson-Lee, PhD, Vishal N. Koparde, PhD, Juliana K. Sampson, PhD, Allison F. Scalora, MS, Haniya Khalid, BS, Nihar Sheth, MS, Phil Griffith, MS, Myrna G. Serrano, PhD, Vladimir Lee, PhD, Catherine H. Roberts, PhD, Michael C. Neale, PhD, Gregory A. Buck, PhD, Masoud Manjili, PhD, Amir Ahmed Toor, MD Biology of Blood and Marrow Transplantation Volume 20, Issue 2, Pages S269-S270 (February 2014) DOI: 10.1016/j.bbmt.2013.12.454 Copyright © 2014 Terms and Conditions

Figure 1 Comparison of total number of SNP (WES) in each DRP, in silico derived nona-peptides with strong binding (IC50 <50 nm) and strong-week binding (IC50 <500 nM). Biology of Blood and Marrow Transplantation 2014 20, S269-S270DOI: (10.1016/j.bbmt.2013.12.454) Copyright © 2014 Terms and Conditions

Figure 2 IC50 values of peptide-HLA complexes for MRD (red) URD (blue) for IC50 < 500nm. Data for a single allele presented. Peptides below the black line are strong binding (IC50 <50 nm). Biology of Blood and Marrow Transplantation 2014 20, S269-S270DOI: (10.1016/j.bbmt.2013.12.454) Copyright © 2014 Terms and Conditions