Chapter 10.3 Section 3 Regulating The Cell Cycle Objectives Describe how the cell cycle is controlled in eukaryotic cells. Relate the role of the cell cycle to the onset of cancer.

Chapter 10.3 New Vocabulary Checkpoint Cancer Carcinogen Mutagen Section 3 Regulating The Cell Cycle New Vocabulary Checkpoint Cancer Carcinogen Mutagen Apoptosis P53 Cyclin Oncogene

Control of the Cell Cycle Chapter 10.3 Section 3 Regulating The Cell Cycle Control of the Cell Cycle How exactly does a cell know when to divide… or not divide? The cell has three inspection points, called ___________________ that provide feedback which will _________ or ____________ the occurrence of the next phase checkpoints trigger prevent

Chapter 10.3 G1 Checkpoint Growth large healthy cyclins Section 3 Regulating The Cell Cycle G1 Checkpoint Growth ____________________checkpoint As long as the cell is _________ enough and ________________, cell proteins called ________ will trigger the synthesis of DNA large healthy cyclins

Chapter 10.3 G2 Checkpoint synthesis correct mitosis Section 3 Regulating The Cell Cycle G2 Checkpoint synthesis DNA _______________ checkpoint DNA polymerases check and ____________ any errors made while copying the DNA If the DNA has been copied correctly, cyclins will trigger the start of _______________ correct mitosis

Chapter 10.3 p53 apoptosis malfunctioning absent Section 3 Regulating The Cell Cycle If too much damage has accumulated in the copied DNA, another protein called _______ can halt division and signal for _____________________, which is cell death… Half of all human cancers result from a ______________ or _______________ p53 protein p53 apoptosis malfunctioning absent

Chapter 10.3 M Checkpoint Mitosis exit growth _____________ checkpoint Section 3 Regulating The Cell Cycle M Checkpoint Mitosis _____________ checkpoint Triggers the _________ from mitosis Once cell division is complete, a cell will reenter the _____________ stage exit growth

Chapter 6 oncogenes damaged mutated cancer Section 3 Regulating The Cell Cycle When Control Is Lost: Cancer Certain genes, called _________________, contain the information necessary to make the proteins that regulate cell growth and division. If one of these genes is ________________ or ________________, cell reproduction may occur at an uncontrolled rate The uncontrolled replication of cells results in _________________________ oncogenes damaged mutated cancer

Chapter 10.3 UV radiation smoking poor diet pesticides pollution Section 3 Regulating The Cell Cycle What are some factors that can damage or mutate your cells? ___________________ Any factor that can cause your cells to mutate is called a __________________ UV radiation smoking poor diet pesticides pollution mutagen

Chapter 10.3 control rapid tumor nutrients Section 3 Regulating The Cell Cycle Once damaged… The cell loses ______________ of the cell cycle _________________ division occurs A ___________ forms, blocking ______________ from reaching nearby healthy cells If you develop cancer in somatic cells, like your lung cells, will your offspring inherit lung cancer? control rapid tumor nutrients No…only mutations in the DNA of sex cells are inherited

Chapter 10.3 Objective 2 Three checkpoints and proteins called Section 3 Regulating The Cell Cycle Objective 2 Describe how the cell cycle is controlled in eukaryotic cells Three checkpoints and proteins called cyclins control the cell cycle

Chapter 10.3 Objective 3 If the cell loses control of the cell cycle Section 3 Regulating The Cell Cycle Objective 3 Relate the role of the cell cycle to the onset of cancer If the cell loses control of the cell cycle and divides too quickly, cancer results