Biological clustering supports both “Dutch” and “British” hypotheses of asthma and chronic obstructive pulmonary disease Michael A. Ghebre, MSc, Mona.

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Presentation transcript:

Biological clustering supports both “Dutch” and “British” hypotheses of asthma and chronic obstructive pulmonary disease Michael A. Ghebre, MSc, Mona Bafadhel, PhD, Dhananjay Desai, MBBS, Suzanne E. Cohen, PhD, Paul Newbold, PhD, Laura Rapley, PhD, Jo Woods, PhD, Paul Rugman, PhD, Ian D. Pavord, MD, Chris Newby, PhD, Paul R. Burton, MD, Richard D. May, PhD, Chris E. Brightling, PhD Journal of Allergy and Clinical Immunology Volume 135, Issue 1, Pages 63-72.e10 (January 2015) DOI: 10.1016/j.jaci.2014.06.035 Copyright © 2014 The Authors Terms and Conditions

Fig 1 Discriminant function of demographic, clinical, lung function, and sputum cytokines characteristics across asthma and COPD. Hollow triangles indicate asthma and hollow circles indicate COPD. Journal of Allergy and Clinical Immunology 2015 135, 63-72.e10DOI: (10.1016/j.jaci.2014.06.035) Copyright © 2014 The Authors Terms and Conditions

Fig 2 The 3 identified biological clusters presented using subjects' discriminant scores. Hollow triangles indicate eosinophilic asthma dominant (95% asthma, n = 58); bold triangle and bold circle, neutrophilic asthma and COPD (overlap) dominant (59.6% asthma, n = 47); hollow circle, COPD dominant (95% COPD, n = 41); bold triangle, overlapped asthma; bold circle, overlapped COPD. Journal of Allergy and Clinical Immunology 2015 135, 63-72.e10DOI: (10.1016/j.jaci.2014.06.035) Copyright © 2014 The Authors Terms and Conditions

Fig 3 Absolute IL-1β concentrations on a log scale (base 10) across the 3 identified biological clusters. A, Asthma; C, COPD. P is the P value for mean comparison between cluster 1 or cluster 3 versus cluster 2 (overlap). Journal of Allergy and Clinical Immunology 2015 135, 63-72.e10DOI: (10.1016/j.jaci.2014.06.035) Copyright © 2014 The Authors Terms and Conditions

Fig 4 Cytokine profiles in the test and the validation groups using linear discriminant analysis or IL-1β cutoff and disease for cluster 1 (A), cluster 2 (B), and cluster 3 (C). Circles indicate test study, triangles indicate validation using linear discriminant analysis, and rectangles indicate validation using IL-1β cutoff at 130 pg/mL and disease status (asthma or COPD). The y-axes depict the mean z value (standardized) of each cytokine in each test and validation subgroup. Journal of Allergy and Clinical Immunology 2015 135, 63-72.e10DOI: (10.1016/j.jaci.2014.06.035) Copyright © 2014 The Authors Terms and Conditions

Fig E1 Sputum cytokines, which discriminated across asthma and COPD. ROC AUC with 95% CI illustrating biomarkers that predict asthma (A) or COPD (B). Journal of Allergy and Clinical Immunology 2015 135, 63-72.e10DOI: (10.1016/j.jaci.2014.06.035) Copyright © 2014 The Authors Terms and Conditions

Fig E2 Cytokines across bacterial colonization and low-bacterial colonization. ROC AUC with 95% CI illustrating biomarkers that predict bacterial colonization. Journal of Allergy and Clinical Immunology 2015 135, 63-72.e10DOI: (10.1016/j.jaci.2014.06.035) Copyright © 2014 The Authors Terms and Conditions

Fig E3 Absolute TNF-α concentrations on a log scale (base 10) across the 3 identified biological clusters. A, Asthma; C, COPD. P is the P value for mean comparison between cluster 1 or cluster 3 versus cluster 2 (overlap). Journal of Allergy and Clinical Immunology 2015 135, 63-72.e10DOI: (10.1016/j.jaci.2014.06.035) Copyright © 2014 The Authors Terms and Conditions