Effect of intravenous N-acetylcysteine on outcomes after coronary artery bypass surgery: A randomized, double-blind, placebo-controlled clinical trial

Slides:

Advertisements

Similar presentations

Lost in translation The Journal of Thoracic and Cardiovascular Surgery

Advertisements

Manuel J. Antunes, MD, PhD, DSc

Effect of intravenous N-acetylcysteine on outcomes after coronary artery bypass surgery: A randomized, double-blind, placebo-controlled clinical trial

Increased incidence of acute ascending aortic dissection with off-pump aortocoronary bypass surgery? Olivier Chavanon, MD, Michel Carrier, MD, Raymond.

Off-pump coronary artery bypass grafting does not preserve renal function better than on-pump coronary artery bypass grafting: Results of a case-matched.

Long-term results after surgical treatment of paravalvular leak in the aortic and mitral position Ismail Bouhout, MD, MSc, Amine Mazine, MD, MSc, Aly.

Aly Ghoneim, MD, Ismail Bouhout, MD, Louis P

Postinfarction Ventricular Septal Defects: Towards a New Treatment Algorithm? Simon Maltais, MD, MS, Reda Ibrahim, MD, Arsène-Joseph Basmadjian, MD, Michel.

The days of future past Neel K. Ranganath, MD, Aubrey C. Galloway, MD

Building a bioartificial heart: A 3-song saga

Right internal thoracic artery or saphenous vein grafting

Early Outcomes with Rapid-deployment vs Stented Biological Valves: A Propensity- match Analysis Anthony Nguyen, MD, MSc, Louis-Mathieu Stevens, MD, PhD,

Why surgery won the SYNTAX trial and why it matters

Form ever follows function

William M. DeCampli, MD, PhD

Multilevel data analysis: What? Why? How?

Statin Treatment Equalizes Long-Term Survival Between Patients With Single and Bilateral Internal Thoracic Artery Grafts Michel Carrier, MD, Mariève.

Harold L. Lazar, MD The Journal of Thoracic and Cardiovascular Surgery

Cold blood cardioplegia reduces the increase in cardiac enzyme levels compared with cold crystalloid cardioplegia in patients undergoing aortic valve.

Commentary: Pursuit of the green jacket: Mastery of the long and short games Daniel P. Raymond, MD The Journal of Thoracic and Cardiovascular Surgery

A cluster of cases of Aspergillus endocarditis after cardiac surgery

The lord of the rings Antonio Miceli, MD, PhD

Igor E. Konstantinov, MD, PhD, FRACS

The unintended consequences in clinical research

Surgical economics: MACRA, MIPS, and bundles—Lessons learned in the first 3 years of a coronary artery bypass grafting alternative payment model Daniel.

Kyle W. Riggs, MD, David L.S. Morales, MD

Franco Stella, MD, PhD, Francesco Petrella, MD

Twenty-Year Experience With the CarboMedics Mechanical Valve Prosthesis Denis Bouchard, MD, Amine Mazine, MD, Louis-Mathieu Stevens, MD, Michel Pellerin,

The assessment of cost effectiveness and the effectiveness of cost assessment in cardiothoracic surgery Vinay Badhwar, MD The Journal of Thoracic and.

It's not “just a shunt” but sometimes it should be…

Military surgeons just want to have fun

Do we need a bibliometrician to know which way the wind is blowing?

A first start for lung transplantation?

Pulmonary metabolism of endothelin 1 during on-pump and beating heart coronary artery bypass operations Patrick Mathieu, MDa, Jocelyn Dupuis, MD, PhDb,

Surgical treatment of a rare association: Aberrant right coronary origination, coronary arteriovenous fistula, and aortic root aneurysm Frédéric Vanden.

Confusion still exists regarding postoperative delirium and its etiology after esophagectomy Robert B. Cameron, MD The Journal of Thoracic and Cardiovascular.

Michel Carrier, MD, Michel Pellerin, MD, Louis P Perrault, MD, PhD, B

Joseph A. Dearani, MD, Michael J. Ackerman, MD, PhD

Chronic obstructive pulmonary disease severity influences outcomes after off-pump coronary artery bypass Benjamin Medalion, MD, Michael G. Katz, MD,

Jeevanantham Rajeswaran, PhD, Eugene H. Blackstone, MD

Derrick Y. Tam, MD, Stephen E. Fremes, MD, MSc

Fenton H. McCarthy, MD, MS, Nimesh D. Desai, MD, PhD

Guidelines should bother us, not comfort us

Attachment disorder in thoracoabdominal surgery

Statin in Combination With β-Blocker Therapy Reduces Postoperative Stroke After Coronary Artery Bypass Graft Surgery Denis Bouchard, MD, Michel Carrier,

The Ross procedure: Time to reevaluate the guidelines

Conservative management of an intrapericardial contained rupture of the right pulmonary artery in blunt trauma: A good idea? Pierre Demondion, MD, Patrick.

Passing the torch The Journal of Thoracic and Cardiovascular Surgery

Prognosis and “granularity”: Building on staging foundations?

Ralph S. Mosca, MD The Journal of Thoracic and Cardiovascular Surgery

Meta-analysis of randomized trials on the efficacy of posterior pericardiotomy in preventing atrial fibrillation after coronary artery bypass surgery

Landiolol hydrochloride for prevention of atrial fibrillation after coronary artery bypass grafting: New evidence from the PASCAL trial Akira Sezai,

The Journal of Thoracic and Cardiovascular Surgery

Discussion The Journal of Thoracic and Cardiovascular Surgery

Effect of one-stop hybrid coronary revascularization on postoperative renal function and bleeding: A comparison study with off-pump coronary artery bypass.

The future of cardiac surgery training: A survival guide

Methicillin-resistant Staphylococcus aureus infection in a cardiac surgical unit Michel Carrier, MDa, Richard Marchand, MDb,c, Pierre Auger, MDb,c, Yves.

Improved quality and cost-effectiveness of coronary artery bypass grafting in the United States from 1988 to 2005 Howard K. Song, MD, PhD, Brian S. Diggs,

“The more things change…”: The challenges ahead

Commentary: Judgment day: Should you add atrial fibrillation ablation?

Appropriate Use Criteria for coronary revascularization in patients with stable ischemic heart disease: What the surgeon needs to know Harold L. Lazar,

Apples remain apples NO matter what

Lung cancer randomized controlled trials should compare stereotactic body radiation therapy with observation, NOT surgery Raja M. Flores, MD The Journal.

A large international single-center case-series of coronary artery fistulas in children: When high clinical research standards adopted globally create.

The evolution of cardiothoracic critical care

Did you like Terminator 3 better than Terminator 2

Which biologic valve should we select for the 45- to 65-year-old age group requiring aortic valve replacement? F. Dagenais, MD, P. Cartier, MD, P. Voisine,

Journal changes and initiatives

IS local wound infection rate more important than long-term graft patency in coronary artery bypass grafting? Tomislav Kopjar, MD, PhD, Michael R. Dashwood,

Intraoperative endocardial ultrasonography: Improving safety in mitral valve surgery Juan A. Crestanello, MD The Journal of Thoracic and Cardiovascular.

Presentation transcript:

Effect of intravenous N-acetylcysteine on outcomes after coronary artery bypass surgery: A randomized, double-blind, placebo-controlled clinical trial Ismail El-Hamamsy, MD, Louis-Mathieu Stevens, MD, Michel Carrier, MD, Michel Pellerin, MD, Denis Bouchard, MD, Philippe Demers, MD, Raymond Cartier, MD, Pierre Page, MD, Louis P. Perrault, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 133, Issue 1, Pages 7-12 (January 2007) DOI: 10.1016/j.jtcvs.2006.05.070 Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 IL-6 levels at different time points between NAC and placebo groups (P = NS). IL-6, interleukin-6; NAC, N-acetylcysteine. The Journal of Thoracic and Cardiovascular Surgery 2007 133, 7-12DOI: (10.1016/j.jtcvs.2006.05.070) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Comparison of postoperative troponin T levels between NAC group and placebo. NAC, N-acetylcysteine. The Journal of Thoracic and Cardiovascular Surgery 2007 133, 7-12DOI: (10.1016/j.jtcvs.2006.05.070) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Comparison of postoperative CK-MB levels between NAC group and placebo. CK-MB, creatine kinase; NAC, N-acetylcysteine. The Journal of Thoracic and Cardiovascular Surgery 2007 133, 7-12DOI: (10.1016/j.jtcvs.2006.05.070) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Comparison of serum creatinine levels between NAC group and placebo (μmol/L). NAC, N-acetylcysteine. POD, Postoperative day. The Journal of Thoracic and Cardiovascular Surgery 2007 133, 7-12DOI: (10.1016/j.jtcvs.2006.05.070) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions