Why NAD+ Declines during Aging: It’s Destroyed

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Presentation transcript:

Why NAD+ Declines during Aging: It’s Destroyed Michael B. Schultz, David A. Sinclair Cell Metabolism Volume 23, Issue 6, Pages 965-966 (June 2016) DOI: 10.1016/j.cmet.2016.05.022 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 CD38 Regulates Metabolism during Aging through Modulating NAD+ Levels and SIRT3 Activity CD38 is a membrane-bound NADase that hydrolyzes NAD+ to nicotinamide and (cyclic-)ADP-ribose. Its protein levels increase during aging, with a corresponding increase in NADase activity and declining NAD+ levels. Mice deficient for CD38 are protected from mitochondrial dysfuntion and diabetes during aging. Many of these effects are mediated through the mitochondrial sirtuin SIRT3. As CD38 also degrades NMN, the CD38 knockout mice also are more sensitive to treatment with NAD+ precursors. Cell Metabolism 2016 23, 965-966DOI: (10.1016/j.cmet.2016.05.022) Copyright © 2016 Elsevier Inc. Terms and Conditions