Cling-E. coli : Bacteria on target Harvard iGEM 2007 Ellenor Brown Stephanie Lo Alex Pickett Sammy Sambu Kevin Shee Perry Tsai Shaunak Vankudre George Xu
The motivation To develop a system for directing bacteria to a target of interest and effecting downstream activity Bacterial targeting is necessary for spatially-specific activity in the body or in nature Post-targeting activity and transmembrane signalling are the next step in engineering genetic circuits that interface extracellular and intracellular environments
The vision: Bacterial targeting via membrane display
The vision: Inter-cellular activation via Lux quorum-sensing
The vision: Intra-cellular activation via Fec signal transduction