Bronchioloalveolar Carcinoma (Lepidic Growth) Component Is a More Useful Prognostic Factor than Lymph Node Metastasis Yoichi Anami, MD, Tatsuo Iijima,

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Bronchioloalveolar Carcinoma (Lepidic Growth) Component Is a More Useful Prognostic Factor than Lymph Node Metastasis Yoichi Anami, MD, Tatsuo Iijima, MD, Kenji Suzuki, MD, Jun Yokota, MD, Yuko Minami, MD, Hiromi Kobayashi, MD, Kaishi Satomi, MD, Yoshimasa Nakazato, MD, Masafumi Okada, MD, Masayuki Noguchi, MD Journal of Thoracic Oncology Volume 4, Issue 8, Pages 951-958 (August 2009) DOI: 10.1097/JTO.0b013e3181ad8631 Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Positive stainings of carcinoembryonic antigen (CEA) (A), p53 (B), MIB-1 labeling index (C), p27 (D), epidermal growth factor receptor (EGFR, E), phosphorylated-EGFR (pEGFR, F), Cox-2 (G), neuronatin (H), γH2AX (I), and TTF-1 (J). K, Representative histologic slide of adenocarcinoma with bronchioloalveolar component more than 50%. L, Representative histology of micropapillary growth. Journal of Thoracic Oncology 2009 4, 951-958DOI: (10.1097/JTO.0b013e3181ad8631) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Using the Kaplan-Meier method, survival curves for patients with small adenocarcinoma (n = 139) were stratified according to positive markers. Patients with more than 50% of bronchioloalveolar cell carcinoma (BAC)/lepidic growth (LG) component showed significantly more favorable survival than those with less than 50% BAC component (A). Patients with positive phosphorylated-EGFR (pEGFR) staining showed significantly less favorable survival than those who were negative for pEGFR (B). Patients with an MIB-1 labeling index of more than 10% showed significantly less favorable survival than those with an MIB-1 index of less than 10% (C). Patients with more than 60% of the tumor cells stained showed significantly less favorable prognosis than those with 60% or less of tumor cells stained (D). Journal of Thoracic Oncology 2009 4, 951-958DOI: (10.1097/JTO.0b013e3181ad8631) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Survival curves for patients with small adenocarcinoma mixed bronchioloalveolar cell carcinoma (BAC) component (n = 70) were stratified again according to the positive markers. The >50% BAC/lepidic growth (LG) component and >50% TTF-1 were significant prognostic factors (A and B). Journal of Thoracic Oncology 2009 4, 951-958DOI: (10.1097/JTO.0b013e3181ad8631) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions