Postthrombotic vein wall remodeling: Preliminary observations

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Presentation transcript:

Postthrombotic vein wall remodeling: Preliminary observations Kristopher B. Deatrick, MD, Megan Elfline, MS, Nichole Baker, RVT, Catherine E. Luke, LVT, Susan Blackburn, MS, Catherine Stabler, RN, Thomas W. Wakefield, MD, Peter K. Henke, MD Journal of Vascular Surgery Volume 53, Issue 1, Pages 139-146 (January 2011) DOI: 10.1016/j.jvs.2010.07.043 Copyright © 2011 Society for Vascular Surgery Terms and Conditions

Fig 1 A, Example of grayscale image of unaffected contralateral vein image in longitudinal segment. B, Example of a postthrombotic thickened vein wall segment in a patient with a resolved thrombus at 6 months. Arrows indicate the vein wall hyperechogenicity. C, Vein wall thickness in nonthrombosed subjects and those with an acute DVT over time. D, Comparison of patient's vein wall thickness in those who did and did not resolve their DVT at 6 months. *P < .05. Journal of Vascular Surgery 2011 53, 139-146DOI: (10.1016/j.jvs.2010.07.043) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

Fig 2 A, Comparison of serum MMP-9 in patients without DVT as compared with patients with acute DVT. B, Comparison of serum D-dimer in subjects without DVT versus DVT patients. *P < .05. Journal of Vascular Surgery 2011 53, 139-146DOI: (10.1016/j.jvs.2010.07.043) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

Fig 3 A, P-selectin trended toward an increase at enrollment, but no difference was observed at 6 months. B, P-selectin was higher at 1 month in those patients who resolved their DVT as compared with those who had a chronic thrombus. *P < .05. Journal of Vascular Surgery 2011 53, 139-146DOI: (10.1016/j.jvs.2010.07.043) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

Fig 4 A, Peripheral leukocyte P-selectin ligand gene expression was reduced in DVT patients compared with non-DVT subjects at enrollment. B, TLR-9 expression was reduced in DVT patients as compared with non-DVT subjects at enrollment. C, P-selectin was increased at enrollment in those who resolved their thrombus as compared with those with chronic thrombus. D, TLR-4 expression was reduced at enrollment in those patients who had persistent thrombus. *P ≤ .05. Journal of Vascular Surgery 2011 53, 139-146DOI: (10.1016/j.jvs.2010.07.043) Copyright © 2011 Society for Vascular Surgery Terms and Conditions