Clinical outcome of autologous chondrocyte implantation is correlated with infrared spectroscopic imaging-derived parameters A. Hanifi, J.B. Richardson,

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Presentation transcript:

Clinical outcome of autologous chondrocyte implantation is correlated with infrared spectroscopic imaging-derived parameters A. Hanifi, J.B. Richardson, J.H. Kuiper, S. Roberts, N. Pleshko Osteoarthritis and Cartilage Volume 20, Issue 9, Pages 988-996 (September 2012) DOI: 10.1016/j.joca.2012.05.007 Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Percentage LSI 9–65months post-ACI treatment (A) for each individual patient, (B) vs patient age, and (C) vs time of biopsy. Osteoarthritis and Cartilage 2012 20, 988-996DOI: (10.1016/j.joca.2012.05.007) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 IHC staining for types I and II collagen antibodies from of a subset of ACI-treated biopsy samples. Osteoarthritis and Cartilage 2012 20, 988-996DOI: (10.1016/j.joca.2012.05.007) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 FT-IRIS images from a subset of ACI-treated biopsy samples and from normal cartilage. The red and dark blue in the color scales indicate the highest and lowest content, respectively, for (A) collagen, (B) PG, (C) relative PG, (D) collagen helical integrity, and (E) collagen fibril orientation, where values less than 1.7 indicate fibers perpendicular to the surface, between 1.7 and 2.7 indicate randomly aligned fibers, and larger than 2.7 indicate collagen fibers with orientation parallel to the articular surface, respectively. Osteoarthritis and Cartilage 2012 20, 988-996DOI: (10.1016/j.joca.2012.05.007) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 FT-IRIS-derived parameters from a subset of ACI-treated biopsy samples. (A) PG/collagen content, and (B) collagen helical integrity. Corresponding IHC image of (C) collagen type II staining, and (D) histology image of H&E staining. Osteoarthritis and Cartilage 2012 20, 988-996DOI: (10.1016/j.joca.2012.05.007) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Correlation of IHC area and intensity scores for type II collagen with FT-IRIS-derived parameters and histology or IHC scores; (A) IHC intensity score vs PG content, p < 0.0001 (95% CI: 0.93–0.97), (B) IHC intensity score vs collagen integrity, p < 0.0001 (95% CI: 0.96–0.98), (C) IHC area score vs OsScore, p = 0.001 (95% CI: 0.43–0.93). Osteoarthritis and Cartilage 2012 20, 988-996DOI: (10.1016/j.joca.2012.05.007) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 6 Correlation of FT-IRIS-derived parameters with percentage LSI and IHC area score values; (A) Collagen integrity vs percentage LSI, p = 0.001 (95% CI: 0.43–0.93), (B) PG content vs percentage LSI, p = 0.006 (95% CI: 0.25–0.89), (C) IHC area score vs percentage LSI, p = 0.004 (95% CI: 0.27–0.89), (D) OsScore vs percentage LSI, p = 0.006 (95% CI: 0.23–0.88). Osteoarthritis and Cartilage 2012 20, 988-996DOI: (10.1016/j.joca.2012.05.007) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions