Final Presentation [work in progress… work completed for Week 11 Journal Assignment] Kara Dismuke.

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Final Presentation [work in progress… work completed for Week 11 Journal Assignment] Kara Dismuke

Table 1: As we tightened the restriction on the p-value, the percentages of significant results decreased with the Bonferroni-adjusted p-value proving to be most selective for obtaining significant results (for both the wild type strain and dZAP1 strain) ANOVA WT dZAP1 p < 0.05 2378/6189 (31.42%) 2264/6189 (36.58%) p < 0.01 1527/6189 (24.67%) 1445/6189 (23.35%) p < 0.001 860/6189 (13.90%) 792/6189 (12.80%) p < 0.0001 460/6189 (7.43%) 414/6189 (6.69%) B-H p < 0.05 1656/6189 (26.76%) 1538/6189 (24.85%) Bonferroni p < 0.05 228/6189 (3.68%) 192/6189 (3.10%) From Excel data/calculations

STEM Profile Results for dZAP1 Each box corresponds to a model expression profile. Colored profiles have a statistically significant number of genes assigned; they are arranged in order from most to least significant p value. Profiles with the same color belong to the same cluster of profiles. The number in each box is simply an ID number for the profile. Note: colored profiles have a statistically significant number of genes assigned

Results: Profile 45

Results: Profile 22

Results: Profile 9

Results: Profile 48

Results: Profile 7

Results: Profile 28

Gene regulatory network for matrix of binding AND expression (5 edges) Kristen’s graph (from her data)

Gene regulatory network for documented binding PLUS expression (141 edges) Kristen’s graph (from her data)

Gene regulatory network for DNA binding ONLY (35 edges) Kristen’s graph (from her data)