Papillary Thyroid Cancer Treated at the Mayo Clinic, 1946 Through 1970: Initial Manifestations, Pathologic Findings, Therapy, and Outcome WILLIAM M. McCONAHEY, M.D., IAN D. HAY, M.B., Ph.D. Mayo Clinic Proceedings Volume 61, Issue 12, Pages 978-996 (December 1986) DOI: 10.1016/S0025-6196(12)62641-X Copyright © 1986 Mayo Foundation for Medical Education and Research Terms and Conditions
Fig. 1 Age distribution of 583 female and 276 male patients with papillary thyroid cancer, who were treated at the Mayo Clinic during the period 1946 through 1970. Mayo Clinic Proceedings 1986 61, 978-996DOI: (10.1016/S0025-6196(12)62641-X) Copyright © 1986 Mayo Foundation for Medical Education and Research Terms and Conditions
Fig. 2 Size distribution of 859 primary papillary thyroid cancer tumors treated during 1946 through 1970 at the Mayo Clinic. Mayo Clinic Proceedings 1986 61, 978-996DOI: (10.1016/S0025-6196(12)62641-X) Copyright © 1986 Mayo Foundation for Medical Education and Research Terms and Conditions
Fig. 3 Cumulative occurrence of postoperative events: metastatic nodes (57 patients), local recurrences (49 patients), or distant metastatic lesions (40 patients). Based on 800 patients with complete surgical resection and no distant metastatic lesions on initial examination. Mayo Clinic Proceedings 1986 61, 978-996DOI: (10.1016/S0025-6196(12)62641-X) Copyright © 1986 Mayo Foundation for Medical Education and Research Terms and Conditions
Fig. 4 Incidence rates of postoperative events by age of patients. Left Panel, Postoperative metastatic nodes. Right Panel, Local recurrences and distant metastatic lesions. Mayo Clinic Proceedings 1986 61, 978-996DOI: (10.1016/S0025-6196(12)62641-X) Copyright © 1986 Mayo Foundation for Medical Education and Research Terms and Conditions
Fig. 5 Cumulative mortality for 859 patients with papillary thyroid cancer, showing percentage dead when only death from thyroid cancer was considered (bottom curve) and when death from all causes was considered (top curve). Expected survival of 859 persons of same age and sex and with same date of treatment but living under mortality conditions of North Central United States is also plotted (middle curve). Mayo Clinic Proceedings 1986 61, 978-996DOI: (10.1016/S0025-6196(12)62641-X) Copyright © 1986 Mayo Foundation for Medical Education and Research Terms and Conditions
Fig. 6 Cumulative mortality from papillary thyroid cancer, plotted by age group. Mayo Clinic Proceedings 1986 61, 978-996DOI: (10.1016/S0025-6196(12)62641-X) Copyright © 1986 Mayo Foundation for Medical Education and Research Terms and Conditions
Fig. 7 Cumulative mortality from papillary thyroid cancer, plotted by sex of patients. Mayo Clinic Proceedings 1986 61, 978-996DOI: (10.1016/S0025-6196(12)62641-X) Copyright © 1986 Mayo Foundation for Medical Education and Research Terms and Conditions
Fig. 8 Cumulative mortality from papillary thyroid cancer, plotted by diameter of primary tumor. Mayo Clinic Proceedings 1986 61, 978-996DOI: (10.1016/S0025-6196(12)62641-X) Copyright © 1986 Mayo Foundation for Medical Education and Research Terms and Conditions
Fig. 9 Cumulative mortality from papillary thyroid cancer, plotted by histologic grade of tumor. Mayo Clinic Proceedings 1986 61, 978-996DOI: (10.1016/S0025-6196(12)62641-X) Copyright © 1986 Mayo Foundation for Medical Education and Research Terms and Conditions
Fig. 10 Cumulative mortality from papillary thyroid cancer, plotted by extent of tumor at initial examination. Mayo Clinic Proceedings 1986 61, 978-996DOI: (10.1016/S0025-6196(12)62641-X) Copyright © 1986 Mayo Foundation for Medical Education and Research Terms and Conditions
Fig. 11 Cumulative mortality from papillary thyroid cancer, plotted by presence (“Yes”) or absence (“No”) of prior or concomitant Hashimoto's disease (chronic lymphocytic thyroiditis). Mayo Clinic Proceedings 1986 61, 978-996DOI: (10.1016/S0025-6196(12)62641-X) Copyright © 1986 Mayo Foundation for Medical Education and Research Terms and Conditions
Fig. 12 Cumulative mortality from papillary thyroid cancer, plotted by presence of metastatic cervical nodes or distant metastatic lesions, discovered either on arrival of patient or years after initial diagnosis and treatment. Mayo Clinic Proceedings 1986 61, 978-996DOI: (10.1016/S0025-6196(12)62641-X) Copyright © 1986 Mayo Foundation for Medical Education and Research Terms and Conditions
Fig. 13 Cumulative mortality from papillary thyroid cancer in patients with distant metastatic lesions, plotted by age of patients (younger than 50 years versus 50 years and older). Mayo Clinic Proceedings 1986 61, 978-996DOI: (10.1016/S0025-6196(12)62641-X) Copyright © 1986 Mayo Foundation for Medical Education and Research Terms and Conditions
Fig. 14 Cumulative mortality from papillary thyroid cancer in patients with local recurrence, distant metastatic lesion, or both local and distant recurrences. Left Panel, Patients with intrathyroidal tumors on initial examination. Right Panel, Patients with extrathyroidal tumors. Mayo Clinic Proceedings 1986 61, 978-996DOI: (10.1016/S0025-6196(12)62641-X) Copyright © 1986 Mayo Foundation for Medical Education and Research Terms and Conditions