Short Term Synaptic Plasticity Misha Tsodyks Henry Markram (EPFL) Yun Wang (Tufts) Klaus Pawelzik (Bremen) Wu Si (Peking University) Omri Barak (Technion)

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Presentation transcript:

Short Term Synaptic Plasticity Misha Tsodyks Henry Markram (EPFL) Yun Wang (Tufts) Klaus Pawelzik (Bremen) Wu Si (Peking University) Omri Barak (Technion) Gianluigi Mongillo (Paris V) Mi Yuanyuan (Institute of Basic Medical Sciences, Beijing) Misha Katkov (WIS)

Multineuron Recording

Markram, Wang & Tsodyks PNAS 1998

A Phenomenological Approach to Dynamic Synaptic Transmission 4 Key Synaptic Parameters Absolute strength Probability of release Depression time constant Facilitation time constant 2 Synaptic Variables Resources available (x) Release probability (u) Markram, Wang & Tsodyks PNAS 1998

A Phenomenological Approach to Dynamic Synaptic Transmission 4 Key Synaptic Parameters Absolute strength Probability of release Depression time constant Facilitation time constant 2 Synaptic Variables Resources available (x) Release probability (u) Markram, Wang & Tsodyks PNAS 1998

Phenomenological model of synaptic depression ( )

The fitting process (deterministic model)

Frequency-dependence of post-synaptic response

Frequency-dependence of post-synaptic response

Frequency-dependence of post-synaptic response

The 1/f Law of Release Tsodyks & Markram, PNAS 1997

Redistribution of Synaptic Efficacy (Markram & Tsodyks, Nature 96)

Redistribution of Synaptic Efficacy high u low u

Population signal E(t) Tsodyks, Pawelzik & Markram, Neural Computation 1998

Population signal (Poisson spike trains) E(t): time-dependent firing rate Tsodyks, Pawelzik & Markram, Neural Computation 1998

Steady-state signal:

Tsodyks & Markram, PNAS 1997

Time-dependent signal ‘High-pass filtering’ of the input rate

High-pass filtering of the input rate amplitude Tsodyks and Wu (2013), Scholarpedia

Synchronous change in pre-synaptic rates

Synchronous change in pre-synaptic rates

Synchronous change in pre-synaptic rates (Weber’s law) Abbott et al, Science 1997