Juan Rivera, Lino Tessarollo Immunity

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Presentation transcript:

Genetic Background and the Dilemma of Translating Mouse Studies to Humans Juan Rivera, Lino Tessarollo Immunity Volume 28, Issue 1, Pages 1-4 (January 2008) DOI: 10.1016/j.immuni.2007.12.008 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 What Is the Right Genetic Background? Shown are C57BL/6, 129/Sv, and BALB/c mice, as well as chimeras derived from hybrid C57BL/6×129/Sv embryonic stem cells injected into C57BL/6 and BALB/c blastocysts. An increasing body of work suggests that we should explore multiple mouse strains when studying specific genes to unravel the complex genetic interactions underlying their function and the development of specific pathologies. This broader approach is likely to enhance the relevance of the findings in mouse models to human physiology and disease. Immunity 2008 28, 1-4DOI: (10.1016/j.immuni.2007.12.008) Copyright © 2008 Elsevier Inc. Terms and Conditions