Volume 4, Issue 2, Pages (March 2018)

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Volume 4, Issue 2, Pages 132-134 (March 2018) Lichen planopilaris associated with pembrolizumab in a patient with metastatic melanoma Anna L. Cogen, MD, PhD, Vishwas Parekh, MD, Tara Gangadhar, MD, Jules B. Lipoff, MD JAAD Case Reports Volume 4, Issue 2, Pages 132-134 (March 2018) DOI: 10.1016/j.jdcr.2017.12.002 Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Clinical features of lichen planopilaris and oral ulcers after pembrolizumab. A, Perifollicular erythema with hyperkeratosis and alopecia on vertex scalp surrounding central skin graft, with depigmentation of the hair tuft at the site of metastatic melanoma nodule. B, Hair regrowth and progressive depigmentation of hair at metastatic melanoma nodule after course of oral prednisone, topical clobetasol, and minocycline. C, Shallow ulcer on lateral tongue suggestive of oral lichen planus. JAAD Case Reports 2018 4, 132-134DOI: (10.1016/j.jdcr.2017.12.002) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Histopathology of lichen planopilaris in the context of pembrolizumab therapy. Vertical (A) and horizontal (B) sections of scalp punch biopsy show a lichenoid inflammation limited to the upper portions of the hair follicles. C, The absence of lichenoid inflammation in the interfollicular region. D, Apoptotic keratinocyte (arrow). (Original magnifications: A, ×40; B, ×20; C, ×100; D, ×200.) JAAD Case Reports 2018 4, 132-134DOI: (10.1016/j.jdcr.2017.12.002) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions