Outcomes of patients with severe combined immunodeficiency treated with hematopoietic stem cell transplantation with and without preconditioning Niraj.

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Presentation transcript:

Outcomes of patients with severe combined immunodeficiency treated with hematopoietic stem cell transplantation with and without preconditioning Niraj C. Patel, MD, MS, Javier Chinen, MD, PhD, Howard M. Rosenblatt, MD, I. Celine Hanson, MD, Robert A. Krance, MD, Mary E. Paul, MD, Stuart L. Abramson, MD, PhD, Lenora M. Noroski, MD, Carla M. Davis, MD, Filiz O. Seeborg, MD, Samuel B. Foster, MD, Kathryn S. Leung, MD, Betty S. Brown, MS, Jerome Ritz, MD, William T. Shearer, MD, PhD Journal of Allergy and Clinical Immunology Volume 124, Issue 5, Pages 1062-1069.e4 (November 2009) DOI: 10.1016/j.jaci.2009.08.041 Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, Kaplan-Meier curve analyzing the survival of patients with SCID, including 18 patients who received MMRD or MUD transplants and 5 patients who received MRD transplants. B, Kaplan-Meier curve demonstrating survival of patients with SCID, including 21 patients who received MMRD transplants without host preconditioning, 17 patients who received MMRD/MUD transplants with host preconditioning, and 10 patients who received MRD transplants. The illustration contains data from 23 patients from this study and 25 patients from a previous study.7 Journal of Allergy and Clinical Immunology 2009 124, 1062-1069.e4DOI: (10.1016/j.jaci.2009.08.041) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Lymphocytes in patients with SCID: CD3+ T cells (A), NK+ cells (B), and CD19+ B cells (C) in 13 survivors who received MMRD/MUD bone marrow and CD3+ T cells (D), NK+ cells (E), and CD19+ B cells (F) in 5 survivors who received unmanipulated bone marrow. The 10th and 90th percentile normal values are represented by shaded areas.9 Journal of Allergy and Clinical Immunology 2009 124, 1062-1069.e4DOI: (10.1016/j.jaci.2009.08.041) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Lymphocytes in patients with SCID: CD3+ T cells (A), NK+ cells (B), and CD19+ B cells (C) in 13 survivors who received MMRD/MUD bone marrow and CD3+ T cells (D), NK+ cells (E), and CD19+ B cells (F) in 5 survivors who received unmanipulated bone marrow. The 10th and 90th percentile normal values are represented by shaded areas.9 Journal of Allergy and Clinical Immunology 2009 124, 1062-1069.e4DOI: (10.1016/j.jaci.2009.08.041) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions