Traffic-related air pollution is associated with airway hyperresponsiveness Byoung-Ju Kim, MD, PhD, So-Yeon Lee, MD, PhD, Ji-Won Kwon, MD, Young-Ho Jung,

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Traffic-related air pollution is associated with airway hyperresponsiveness Byoung-Ju Kim, MD, PhD, So-Yeon Lee, MD, PhD, Ji-Won Kwon, MD, Young-Ho Jung, MD, Eun Lee, MD, Song I. Yang, MD, Hyung- Young Kim, MD, Ju-Hee Seo, MD, Hyo-Bin Kim, MD, PhD, Hwan-Cheol Kim, MD, PhD, Jong-Han Leem, MD, PhD, Ho-Jang Kwon, MD, PhD, Soo-Jong Hong, MD, PhD Journal of Allergy and Clinical Immunology Volume 133, Issue 6, Pages 1763-1765.e2 (June 2014) DOI: 10.1016/j.jaci.2014.01.020 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Associations between home proximity to traffic roads and AHR (PC20 ≤ 8 mg/dL). A, Prevalence of new episode of wheezing during the 2-year study period according to home proximity to traffic roads. B, Rates of AHR (PC20 ≤ 8 mg/dL) measured at 2 years after enrollment regardless of the initial AHR state. C, Rates of new development of AHR during the 2-year study period; hence, children need to have negative AHR (PC20 > 8 mg/dL) at enrollment. D, The rates of increased airway responsiveness. The PC20 value was decreased compared with the previous value regardless of crossing the threshold for AHR. Adjusted for age, sex, body mass index, paternal and maternal history of allergy, maternal education, family income, place of residence, environmental tobacco smoke (ETS) at home, and preterm birth. Journal of Allergy and Clinical Immunology 2014 133, 1763-1765.e2DOI: (10.1016/j.jaci.2014.01.020) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Associations between home proximity to traffic roads and AHR (PC20 ≤ 16 mg/dL). A, Rates of AHR (PC20 ≤ 16 mg/dL) measured at 2 years after enrollment regardless of the initial AHR state. B, Rates of new development of AHR during the 2-year study period; hence, the initial AHR had to be negative (PC20 > 16 mg/dL at enrollment). Journal of Allergy and Clinical Immunology 2014 133, 1763-1765.e2DOI: (10.1016/j.jaci.2014.01.020) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions