Osteoimmunology in mucopolysaccharidoses type I, II, VI and VII

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Osteoimmunology in mucopolysaccharidoses type I, II, VI and VII Osteoimmunology in mucopolysaccharidoses type I, II, VI and VII. Immunological regulation of the osteoarticular system in the course of metabolic inflammation V. Opoka-Winiarska, A. Jurecka, A. Emeryk, A. Tylki-Szymańska Osteoarthritis and Cartilage Volume 21, Issue 12, Pages 1813-1823 (December 2013) DOI: 10.1016/j.joca.2013.08.001 Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Metabolic inflammation in MPS disease. IL-1 – interleukin 1β Osteoarthritis and Cartilage 2013 21, 1813-1823DOI: (10.1016/j.joca.2013.08.001) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 A) and (B). Radiographs of pelvis from patients with JIA (A) and MPS VI (B). (A) Asymmetrical sacroiliac joint space: widening of the right space, irregularity, subchondrial erosions, and sclerosis of the right sacroiliac joint. Narrowing of hip joint space. (B) Rounded iliac wings, dysplastic femoral heads, severe hip dysplasia. Osteoarthritis and Cartilage 2013 21, 1813-1823DOI: (10.1016/j.joca.2013.08.001) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 A) and (B). Radiographs of hands from patients with JIA (A) and MPS VI (B). (A) Proximal interphalangeal (PIP) joint swelling (II P, II L, III L), contracture of PIP joints (V P), Narrowing of metacarpophalangeal (MCP), PIP and wrist joints Spacesta. Joint destruction: geodes and erosions of MCP joints (III P, I P, III L), wrist (L and P), and radial-carpal joints (L and P). (B) Claw hand deformity: bullet-shaped phalanges, thickened, short, metacarpal bones with proximal pointing and thin cortices, irregular carpal bones, irregular, broad radial and ulnar epiphysis, distal interphalangeal joint contractures. Osteoarthritis and Cartilage 2013 21, 1813-1823DOI: (10.1016/j.joca.2013.08.001) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions