Microtubule Flux: What Is It Good for? Alexey Khodjakov, Tarun Kapoor  Current Biology  Volume 15, Issue 23, Pages R966-R968 (December 2005) DOI: 10.1016/j.cub.2005.11.017 Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 1 Dynamics of kinetochore fiber microtubules in vertebrate somatic cells. (A) During metaphase tubulin subunits are continuously removed from the minus ends of microtubules at the spindle pole, while kinetochores switch between periods of tubulin polymerization and removing tubulin subunits from microtubule plus ends. As the result, chromosomes oscillate to and away from the pole, while microtubule lattice continuously fluxes poleward. (B–C). At the onset of anaphase kinetochores switch to continuous microtubule depolymerization. As a result, chromosomes move poleward on microtubules (‘Pac-man’) that at the same time are reeled to the pole via minus-end depolymerization (‘Traction fiber’). Current Biology 2005 15, R966-R968DOI: (10.1016/j.cub.2005.11.017) Copyright © 2005 Elsevier Ltd Terms and Conditions