Fig. 8. Gene and protein changes in ALK-dependent STING pathways in human sepsis. Gene and protein changes in ALK-dependent STING pathways in human sepsis.

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Fig. 8. Gene and protein changes in ALK-dependent STING pathways in human sepsis. Gene and protein changes in ALK-dependent STING pathways in human sepsis. (A) Box plots comparing measures of ALK, EGFR, STING, TBK1, and IRF3 mRNA in PBMC samples of sepsis patients (n = 16) and healthy controls (n = 16). The mRNAs are presented as median value (black line), interquartile range (box), and minimum and maximum of all data (black line). *P < 0.05 versus control group, t test. (B) Table depicting clinical characteristics of sepsis patients and healthy control individuals. (C) Western blot analysis of indicated protein expression in PBMC samples of sepsis patients and healthy controls. Ling Zeng et al., Sci Transl Med 2017;9:eaan5689 Published by AAAS