Hematopoiesis Lineage Tree Uprooted: Every Cell Is a Rainbow

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Hematopoiesis Lineage Tree Uprooted: Every Cell Is a Rainbow Karen K. Hirschi, Stefania Nicoli, Kenneth Walsh Developmental Cell Volume 41, Issue 1, Pages 7-9 (April 2017) DOI: 10.1016/j.devcel.2017.03.020 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Generic Models of Lineage Commitment (A) Lineage tree model: The most oligo-potent cell is depicted in white, and transitions via binary fate decisions to ultimately generate distinct cell lineages are depicted in vibrant, distinct colors. (B) Lineage continuum model: All oligo-potent cells are highly transcriptionally diverse and undergo direct lineage commitment to generate distinct cell types, as opposed to transitioning through a series of discrete and stable progenitors. Developmental Cell 2017 41, 7-9DOI: (10.1016/j.devcel.2017.03.020) Copyright © 2017 Elsevier Inc. Terms and Conditions