Towards precision medicine in sepsis: a position paper from the European Society of Clinical Microbiology and Infectious Diseases J. Rello, T.S.R. van.

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Presentation transcript:

Towards precision medicine in sepsis: a position paper from the European Society of Clinical Microbiology and Infectious Diseases J. Rello, T.S.R. van Engelen, E. Alp, T. Calandra, V. Cattoir, W.V. Kern, M.G. Netea, S. Nseir, S.M. Opal, F.L. van de Veerdonk, M.H. Wilcox, W.J. Wiersinga Clinical Microbiology and Infection Volume 24, Issue 12, Pages 1264-1272 (December 2018) DOI: 10.1016/j.cmi.2018.03.011 Copyright © 2018 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 1 Precision medicine in sepsis. The focus of this Position Paper is on the interplay between therapies, pathogens and the host. Regarding the pathogen, microbiologic diagnostic approaches (such as blood cultures (BCs) and rapid diagnostic tests (RDTs)) are discussed, as well as targeted antibiotic treatment. Other topics include the disruption of host immune system and the use of biomarkers in sepsis management, patient stratification and future clinical trial design. Lastly, personalized antibiotic treatment and stewardship are addressed. Clinical Microbiology and Infection 2018 24, 1264-1272DOI: (10.1016/j.cmi.2018.03.011) Copyright © 2018 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions