Improvement of idiopathic membranous nephropathy diagnosis with ultrasensitive quantitative detection of anti-phospholipase A2 receptor Biao Huang, PhD,

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Presentation transcript:

Improvement of idiopathic membranous nephropathy diagnosis with ultrasensitive quantitative detection of anti-phospholipase A2 receptor Biao Huang, PhD, Liang Wang, MD, Ya-nan Cao, MM, Yi Zhang, MS, Jue Zhang, PhD, Hualong Xiao, MB, Qiuhua Zhang, MM, Weidong Wang, MD, Zhuxing Sun, MB, Yu Chen, MD, Zhigang Hu, MM, Huiming Sheng, MD Journal of Allergy and Clinical Immunology Volume 139, Issue 6, Pages 1988-1990.e2 (June 2017) DOI: 10.1016/j.jaci.2016.10.020 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Serum anti-PLA2R-IgG levels for TRFIA results by disease state. The determination accuracy of serum anti-PLA2R-IgG, from high to low, is IMN, lupus erythematosus nephropathy, IgA nephropathy, and other kidney disease. IMN I, IMN II, lupus erythematosus nephropathy, IgA nephropathy, and other kidney disease versus healthy volunteers was P < .0001, P < .0001, P < .0001, P < .0001, P = .0037, respectively. IMN I versus IMN II was P = .0355. ∗∗.0001< P < .001; ∗∗∗P < .0001. Journal of Allergy and Clinical Immunology 2017 139, 1988-1990.e2DOI: (10.1016/j.jaci.2016.10.020) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Serum anti-PLA2R-IgG levels and receiver operating characteristic (ROC) curves for TRFIA results by type of nephropathy. Area-under-the-curve of ROC for sensitivity and specificity of anti-PLA2R-IgG in IgA nephropathy, lupus kidney disease, and IMN were >0.500 (0.7285, 0.8472, 0.9798, respectively). The determination accuracy of serum anti-PLA2R-IgG, from high to low, is IMN, lupus erythematosus nephropathy (LN), and IgA nephropathy. Journal of Allergy and Clinical Immunology 2017 139, 1988-1990.e2DOI: (10.1016/j.jaci.2016.10.020) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Comparison of serum anti-PLA2R-IgG to PLA2R antigen in situ for IMN. PLA2R was detected by indirect immunofluorescence in tissue biopsy samples. Anti-PLA2R-IgG was used to detect PLA2R levels in biopsy samples from each patient to compare with TRFIA results. A-D, Fluorescence intensity increased in these samples. E, Comparison of detection by immunofluorescence and TRFIA. Bars = 50 μm. Journal of Allergy and Clinical Immunology 2017 139, 1988-1990.e2DOI: (10.1016/j.jaci.2016.10.020) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions