Volume 67, Issue 6, Pages 1112-1121 (June 2015) Use of the Prostate Imaging Reporting and Data System (PI-RADS) for Prostate Cancer Detection with Multiparametric Magnetic Resonance Imaging: A Diagnostic Meta- analysis  Esther H.J. Hamoen, Maarten de Rooij, J. Alfred Witjes, Jelle O. Barentsz, Maroeska M. Rovers  European Urology  Volume 67, Issue 6, Pages 1112-1121 (June 2015) DOI: 10.1016/j.eururo.2014.10.033 Copyright © 2014 European Association of Urology Terms and Conditions

Fig. 1 Flow diagram for study inclusion. European Urology 2015 67, 1112-1121DOI: (10.1016/j.eururo.2014.10.033) Copyright © 2014 European Association of Urology Terms and Conditions

Fig. 2 Graph showing the risk of bias and applicability concerns. Judgments of the review authors for each domain presented as a percentage of the studies included. European Urology 2015 67, 1112-1121DOI: (10.1016/j.eururo.2014.10.033) Copyright © 2014 European Association of Urology Terms and Conditions

Fig. 3 Summary of the risk of bias and applicability concerns. Judgments of the review authors for each domain for each study included as listed in Table 1. European Urology 2015 67, 1112-1121DOI: (10.1016/j.eururo.2014.10.033) Copyright © 2014 European Association of Urology Terms and Conditions

Fig. 4 Hierarchic summary receiver operating characteristic (ROC) plot (solid line) plot and summary point (●) with 95% confidence interval (circled area). The dashed line is the line of no discrimination line (area under the curve of 0.5, meaning a worthless test). Squares denote data from individual studies included in the meta-analysis, with the size of each square indicating the relative size of the study population. European Urology 2015 67, 1112-1121DOI: (10.1016/j.eururo.2014.10.033) Copyright © 2014 European Association of Urology Terms and Conditions

Fig. 5 Forest plots of pooled estimates for all studies overall and for different subgroups. PI-RADS=Prostate Imaging Reporting and Data System. Horizontal lines indicate 95% confidence intervals (CIs). European Urology 2015 67, 1112-1121DOI: (10.1016/j.eururo.2014.10.033) Copyright © 2014 European Association of Urology Terms and Conditions

Fig. 6 Linear regression test of funnel plot asymmetry. The statistical nonsignificance (p=0.36) for the slope coefficient suggests a low likelihood of publication bias. Numbers in the data circles indicate the study numbers as listed in Table 1. European Urology 2015 67, 1112-1121DOI: (10.1016/j.eururo.2014.10.033) Copyright © 2014 European Association of Urology Terms and Conditions