Bioavailability and Cardiovascular Effects of Adrenaline Administered by Anapen Autoinjector in Healthy Volunteers  Thierry Duvauchelle, MD, Philippe Robert, PhD, Yves Donazzolo, MD, Sabrina Loyau, PharmD, Bernard Orlandini, MSc, Philippe Lehert, PhD, Jeanne-Marie Lecomte, PhD, Jean-Charles Schwartz, PhD  The Journal of Allergy and Clinical Immunology: In Practice  Volume 6, Issue 4, Pages 1257-1263 (July 2018) DOI: 10.1016/j.jaip.2017.09.021 Copyright © 2017 The Authors Terms and Conditions

Figure 1 Ultrasonographic images of the skin of a normal weight male subject before (left) and after (right) injection of 0.3 mg adrenaline using the Anapen autoinjector. The dotted lines and letter A denote the skin limit (left) or the bolus localization (right). The Journal of Allergy and Clinical Immunology: In Practice 2018 6, 1257-1263DOI: (10.1016/j.jaip.2017.09.021) Copyright © 2017 The Authors Terms and Conditions

Figure 2 Ultrasonographic images of the skin of an overweight female subject before (left) and after (right) injection of 0.3 mg adrenaline using the Anapen autoinjector. The dotted line and letter A denote the skin limit (left) or the bolus localization (right). The Journal of Allergy and Clinical Immunology: In Practice 2018 6, 1257-1263DOI: (10.1016/j.jaip.2017.09.021) Copyright © 2017 The Authors Terms and Conditions

Figure 3 Changes in adrenaline plasma levels and HR according to various conditions. The Journal of Allergy and Clinical Immunology: In Practice 2018 6, 1257-1263DOI: (10.1016/j.jaip.2017.09.021) Copyright © 2017 The Authors Terms and Conditions