Defense and Immunity I. First Lines of Defense A. Mechanical Barriers 1. Skin 2. Respiratory Epithelium 4. Others 3. Fluid Barriers

B. Chemical Barriers C. Cellular Barriers 1. Identify and Explain 1. White Blood Cells = i. Neutrophils, ii. Eosinophils, iii. Macrophages, & iii. N-K Cells Figure 43.1

D. Inflammation 1. Why have an inflammation response? 2. Steps Basophils and their friends Figure 43.8

II. Second Lines of Defense A. Types of Immunity 1. Active 2. Passive Gaining Immunity

3. Immune Response a. Antigens b. Clonal Selection Figure 43.14

c. 1o vs. 2o Response Figure 43.15

B. Cellular Involvement 1. Macrophage a. Structure Figure 43.1

b. Function i. Eat Foreign Antigen ii. Turn on Lymphocytes

c. Production Figure 42.17

2. Lymphocytes a. Structure Figure 42.17

i. T-Lymphocytes  Cell Mediated Immunity b. Function i. T-Lymphocytes  Cell Mediated Immunity ii. B-Lymphocytes  Humoral Immunity c. Production  i. Development, ii. Assignment, Figure 42.17

iii. and Activation Class I MHC versus Class II MHC molecules Figure 43.12 Figure 43.20

iii. Activation Figure 43.16

C. Cell Mediated Immune Response 1. Steps Figure 43.17

D. Humoral Immune Response 1. Steps 2. Antibody Structure Figure 43.14 Figure 43.9

3. Antibodies Types

4. Antibody Functions Figure 43.19

III. Second Lines of Defense: Invertebrates IV. Other Immunity Issues A. Allergies B. Autoimmunity Figure 43.23