Predictors of severe systemic anaphylactic reactions in patients with Hymenoptera venom allergy: Importance of baseline serum tryptase—a study of the.

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Presentation transcript:

Predictors of severe systemic anaphylactic reactions in patients with Hymenoptera venom allergy: Importance of baseline serum tryptase—a study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom Hypersensitivity Franziska Ruëff, MD, Bernhard Przybilla, MD, Maria Beatrice Biló, MD, Ulrich Müller, MD, Fabian Scheipl, Werner Aberer, MD, Joëlle Birnbaum, MD, Anna Bodzenta-Lukaszyk, MD, Floriano Bonifazi, MD, Christoph Bucher, MD, Paolo Campi, MD, Ulf Darsow, MD, Cornelia Egger, MD, Gabrielle Haeberli, MD, Thomas Hawranek, MD, Michael Körner, MD, Iwona Kucharewicz, MD, Helmut Küchenhoff, PhD, Roland Lang, PhD, Oliviero Quercia, MD, Norbert Reider, MD, Maurizio Severino, MD, Michael Sticherling, MD, Gunter Johannes Sturm, MD, Brunello Wüthrich, MD Journal of Allergy and Clinical Immunology Volume 124, Issue 5, Pages 1047-1054 (November 2009) DOI: 10.1016/j.jaci.2009.08.027 Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Smoothed function and 95% confidence band (dashed lines) for the effect of BTCs on the risk of a severe allergic reaction (grade III or IV) after the index field sting (final multivariate model). Odds ratios refer to those of the median of tryptase concentration. The odds ratio of the latter has been set at 1. Journal of Allergy and Clinical Immunology 2009 124, 1047-1054DOI: (10.1016/j.jaci.2009.08.027) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 ROC curve for the final multivariate GAM predicting the risk of a severe allergic reaction (grade III or IV) after the index field sting. Journal of Allergy and Clinical Immunology 2009 124, 1047-1054DOI: (10.1016/j.jaci.2009.08.027) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Correction factor for BTCs. A correction factor is required to account for the patient's tryptase concentration to calculate the predicted risk, p, for a severe anaphylactic reaction in an individual patient (see the Methods section). The correction factor can be derived manually by determining the intersection of the tryptase concentration with the graph. Journal of Allergy and Clinical Immunology 2009 124, 1047-1054DOI: (10.1016/j.jaci.2009.08.027) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions