A. Domínguez-Gil Hurlé, A. Sánchez Navarro, M.J. García Sánchez

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Therapeutic drug monitoring of itraconazole and the relevance of pharmacokinetic interactions A. Domínguez-Gil Hurlé, A. Sánchez Navarro, M.J. García Sánchez Clinical Microbiology and Infection Volume 12, Pages 97-106 (December 2006) DOI: 10.1111/j.1469-0691.2006.01611.x Copyright © 2006 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 1 Kinetic profiles simulated for a single dose of a given anti-infective drug in two hypothetical patients showing different drug clearance levels (100 and 50 mL/min). The differences in the AUC values observed for the two cases will lead to different responses to the same treatment. Clinical Microbiology and Infection 2006 12, 97-106DOI: (10.1111/j.1469-0691.2006.01611.x) Copyright © 2006 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 2 Serum concentration profiles simulated for a multiple dosage regimen for a drug administered alone and in association with an enzymic inhibitor. MTC, maximum tolerated concentration. Clinical Microbiology and Infection 2006 12, 97-106DOI: (10.1111/j.1469-0691.2006.01611.x) Copyright © 2006 European Society of Clinical Infectious Diseases Terms and Conditions