Frequency and abundance of microbial species in the cystic fibrosis (CF) lower airways metagenome. Frequency and abundance of microbial species in the.

Slides:



Advertisements
Similar presentations
Effect of pre-treatment with lipopolysaccharide (LPS) or cystic fibrosis (CF) serum on the production of reactive oxygen species (ROS) by phagocytes from.
Advertisements

Representation of the 15 selected premature termination codons (PTCs) and their corresponding recoded major protein. Representation of the 15 selected.
Results of the AweScoreCF questionnaire completed by 23 adult cystic fibrosis (CF) patients 1 month before and 3 months after initiating ivacaftor–lumacaftor.
Overall survival from enrolment according to operating rule and scenario of organ scarcity for a) scenario R96 (i.e. 96 organs for 100 virtual patients.
Correlation of excessive reactive oxygen species (ROS) production to clinical disease severity. Correlation of excessive reactive oxygen species (ROS)
Flowchart for calculating the relative risk (RR) for cancer X and lung cancer (LC). Flowchart for calculating the relative risk (RR) for cancer X and lung.
Kaplan–Meier curves of 12-month survival after an index chronic obstructive pulmonary disease-related hospitalisation according to level of moderate and.
Distribution of forced expiratory volume in 1 s (FEV1) relative to Global Lung Function Initiative reference values (GLI2012) [10] expressed as FEV1 %
Taxonomic cladograms reporting the most abundant species contributing to the top 95% of the bacterial communities of the lower airways of a) exocrine pancreas.
Dried blood spot for therapeutic drug monitoring. a).
Composition of microbial communities in induced sputa of healthy and mild, moderate, severe or very severe (end-stage) lung disease affected individuals.
A) CT scan of patient number 1, before pembrolizumab; b) CT scan of patient number 1, after 11 pembrolizumab infusions; c) CT scan of patient number 1,
Survival without tracheostomy
Readthrough levels measured for the indicated cystic fibrosis transmembrane conductance regulator (CFTR) premature termination codon mutations, at basal.
Impact of storage conditions on metabolite profiles of sputum samples from persons with cystic fibrosis  Jiangchao Zhao, Charles R. Evans, Lisa A. Carmody,
Displaying the diversity in the natural history of infections of Pseudomonas aeruginosa in patients with non-cystic fibrosis bronchiectasis including:
The correlation between Mycobacterium growth indicator tube (MGIT) time to culture positivity (TTP) and bacterial load count by molecular bacterial load.
Influence of do-not-resuscitate (DNR) order specification on overall survival in chronic obstructive pulmonary disease (COPD) patients (log rank test p
Kaplan–Meier curve for the time until the development of lung cancer in patients with idiopathic pulmonary fibrosis. Kaplan–Meier curve for the time until.
Distribution of lower extremity artery disease (LEAD) Fontaine stages over the combined chronic obstructive pulmonary disease (COPD) Global Initiative.
MRNA expression of collagen-binding integrins in idiopathic pulmonary fibrosis (IPF) lungs. mRNA expression of collagen-binding integrins in idiopathic.
Comparative expression of discoidin domain receptors (DDRs) between healthy lung tissues and those from different types of interstitial lung disease (ILD):
Bland–Altman comparison of lung clearance index (LCI) from multiple breath wash-out following open and modified closed circuit wash-in for both healthy.
Effects of reslizumab on asthma quality of life questionnaire (AQLQ) score in Global Initiative for Asthma (GINA) Step 4 and 5 patients. Effects of reslizumab.
Maturation of recoded cystic fibrosis transmembrane conductance regulator (CFTR) channels. a) Representative Western blot obtained from HEK293 cells expressing.
F. Bittar, J.-M. Rolain  Clinical Microbiology and Infection 
Kaplan–Meier survival curves of all-cause mortality in patients with idiopathic pulmonary fibrosis (IPF). Kaplan–Meier survival curves of all-cause mortality.
Effects of reslizumab on asthma control questionnaire-7 (ACQ-7) score in Global Initiative for Asthma (GINA) Step 4 and 5 patients. Effects of reslizumab.
A white elephant or the elephant in the room
The linear interpolation analysis and the fitting-curve analysis give lower values for lung clearance index (LCI). a) Bland–Altman plots of the absolute.
Performance of FDR methods on filtered microbiome data.
Change in lung clearance index (LCI) (mean±sd % change lung turnovers compared with baseline) based on modelled a, b) continuous and c, d) isolated pre-capillary.
Kaplan–Meier curves of long-term survival in young (
Structure of benthic microbial communities of residential and industrial land use types before and after two rain events in urban waterways are shown.
Changes in weight and body mass index (BMI) associated with quality improvement. Changes in weight and body mass index (BMI) associated with quality improvement.
Clonal strains of Pseudomonas aeruginosa were identified from independent patient-pairs using multilocus sequence typing (MLST). Clonal strains of Pseudomonas.
Mean taxonomic distribution at the phylum level, by sampling method, for all 125 individuals (unrarefied). Mean taxonomic distribution at the phylum level,
A) The flexible 1.9 mm diameter and 900 mm length cryoprobe, b) connected to the cryotherapy equipment. c) Marks on the distal area of the probe (1 cm.
Most frequent words and phrases based on user comments about the registry. Most frequent words and phrases based on user comments about the registry. Word.
Portions of two representative reports, a, c and e) one during noninvasive ventilation through a helmet and b, d and f) the other through mask. Portions.
Novel concepts in evaluating antimicrobial therapy for bacterial lung infections in patients with cystic fibrosis  Geraint B. Rogers, Lucas R. Hoffman,
Phosphorylation levels of discoidin domain receptor (DDR)2.
Pressure increase delivered by the tested automatic continuous positive airway pressure devices during the first 10 min of the bench test. Pressure increase.
Systems biology as a tool to improve idiopathic pulmonary fibrosis (IPF) treatment effectiveness. Systems biology as a tool to improve idiopathic pulmonary.
a) Mortality per time point (p<0
Venn diagram showing the overlap between the various spirometric definitions of airway obstruction and respiratory symptoms. **: p
Aboveground and belowground samples showed differences in their bacterial community structures and compositions, while bulk soil and root communities differed.
A family-based pulmonary rehabilitation (PR) programme enhanced the coping resources of the families of chronic obstructive pulmonary disease patients.
Patients' and partners' experience of anxiety in the Netherlands (NL) and Germany (GE), based on the Generalised Anxiety Disorder-single item questionnaire.
The regression lines between the asynchrony index (AI) and the double true index (DTI) shown for overall data, and for mask and helmet separately. The.
Bacterial community comparison of samples with the most abundant bacterial families (>0.5% mean relative abundance). Bacterial community comparison of.
Differences in a) functional residual capacity (FRC) and b) lung clearance index (LCI) when using all trials in comparison with only the first two trials.
Receiver operating characteristic ROC curve of Lung Clearance Index (LCI)1/40, LCI1/30, LCI1/20, LCI1/10 and inverse forced expiratory volume in 1 s %
Physician perspectives on self-administration of i. v. α1-antitrypsin
Distribution of patients in the first- or second-year follow-up according to the number of acute exacerbations of chronic obstructive pulmonary disease.
Percentage of culture-positive or PCR-positive sputum samples at stable state and exacerbation in year 1 and year 2 (full cohort, year 1 or year 2). a)
Bacterial composition of olive fermentations is affected by microbial inoculation. Bacterial composition of olive fermentations is affected by microbial.
Bland–Altman comparison of functional residual capacity (FRC) measured from multiple breath wash-out following open and modified closed circuit wash-in.
Bacterial sputum microbiomes of a, c) an exocrine pancreas insufficient (PI) cystic fibrosis (CF) patient who is homozygous for the most common cystic.
Effect of the presence of aetiological factors (bacterial or viral infection, or eosinophilic inflammation) at stable visits on the odds of experiencing.
The pulmonary microbiome of children with persistent bacterial bronchitis (PBB). The pulmonary microbiome of children with persistent bacterial bronchitis.
The cystic fibrosis (CF) lower airways metagenome: cumulative presentation of data sets. a, b) Box plot presentation of the absolute frequency and the.
Cystic fibrosis and pregnancy in the modern era: A case control study
Transcriptomic fingerprint of advanced idiopathic pulmonary fibrosis (IPF) lung. Transcriptomic fingerprint of advanced idiopathic pulmonary fibrosis (IPF)
Bench test setting for automatic continuous positive airway pressure (APAP) devices. a) System to simulate the breathing pattern and airway obstructions.
Composition of the most common clusters at the a) onset of the first acute respiratory tract infection (swab A) and b) 3 weeks later (swab B) illustrated.
Composite PRM image (PRM∑) in two exemplar patients with tobacco smoke (TS) exposure and chronic obstructive pulmonary disease (COPD) (top left) and biomass.
Prevalence of acute myocardial infarction (AMI) or other cardiovascular events (CVEs) according to a) Pneumonia Severity Index (PSI) risk classes and b)
Effects of reslizumab on lung function (forced expiratory volume in 1 s; FEV1) in Global Initiative for Asthma (GINA) Step 4 and 5 patients. Effects of.
Percentage of positive results by pathogen among study patients with identified pathogens. “Other” includes respiratory viruses, Stenotrophomonas, Prevotella,
Presentation transcript:

Frequency and abundance of microbial species in the cystic fibrosis (CF) lower airways metagenome. Frequency and abundance of microbial species in the cystic fibrosis (CF) lower airways metagenome. Each dot in the double logarithmic graphs depicts the identification frequency of a species and its mean relative abundance in sputa collected from a, c, e) exocrine pancreas insufficient and b, d, f) exocrine pancreas sufficient CF patients. Abundance was separately normalised for a, b) bacteria, c, d) DNA viruses and e, f) moulds and fungi. The name of a taxon is depicted for the most common and most abundant species. Bacterial taxa belonging to the same phylum are indexed by matching colour. Viruses are differentiated by their host. Moulds and fungi are differentiated by class. Please note that the data points depict the relative abundance of individual species found in the whole dataset of all exocrine pancreas insufficient and sufficient samples. Patricia Moran Losada et al. ERJ Open Res 2016;2:00096-2015 ©2016 by European Respiratory Society