Translational Control: A New Dimension in Embryonic Stem Cell Network Analysis  Wing Y. Chang, William L. Stanford  Cell Stem Cell  Volume 2, Issue 5, Pages 410-412 (May 2008) DOI: 10.1016/j.stem.2008.04.009 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 A Schematic Outlining the Integration of TSSA to Refine Analysis of Regulatory Networks Involved in ESC Differentiation Developing a regulatory network begins with a characterized regulator, such as a transcription factor, involved in lineage specification. Direct transcriptional targets of the factor are initially identified by ChIP-chip or ChIP-sequencing methods that can then be integrated with gene expression data and further refined by translational state data to narrow down crucial regulatory modules. These modules can be integrated with proteomic data to define their function and role during ESC differentiation. Cell Stem Cell 2008 2, 410-412DOI: (10.1016/j.stem.2008.04.009) Copyright © 2008 Elsevier Inc. Terms and Conditions