The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in sheep and goats C.B. Little, M.M. Smith, M.A.

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The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in sheep and goats C.B. Little, M.M. Smith, M.A. Cake, R.A. Read, M.J. Murphy, F.P. Barry Osteoarthritis and Cartilage Volume 18, Pages S80-S92 (October 2010) DOI: 10.1016/j.joca.2010.04.016 Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Anatomy of the sheep knee/stifle joint. Abbreviations: LCL = lateral collateral ligament; ACL and PCL = anterior and posterior cruciate ligaments; LDE = long digital extensor; PT = popliteal tendon; MM and LM = medial and lateral meniscus; MFC and LFC = medial and lateral femoral condyle; TG = trochlear groove of distal femur. Osteoarthritis and Cartilage 2010 18, S80-S92DOI: (10.1016/j.joca.2010.04.016) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Macroscopic scoring of cartilage pathology in the tibial and femoral condyles of sheep following meniscectomy-induced OA. The score based on Table IIIA for the cartilage pathology of the lateral and medial (left and right sides, respectively in each image) tibial or femoral condyle is shown in each image. Osteoarthritis and Cartilage 2010 18, S80-S92DOI: (10.1016/j.joca.2010.04.016) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Macroscopic scoring of osteophytosis in the tibial and femoral condyles of sheep following meniscectomy-induced OA. The score based on Table IIIB for the osteophyte development in the medial and lateral (left and right sides, respectively in each image) tibial or femoral condyle is shown in each image. Osteoarthritis and Cartilage 2010 18, S80-S92DOI: (10.1016/j.joca.2010.04.016) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Macroscopic scoring of synovial pathology in the tibial plateau and femoral condyle of sheep following meniscectomy-induced OA. The score is based on the table reported for scoring synovial pathology in dogs. Osteoarthritis and Cartilage 2010 18, S80-S92DOI: (10.1016/j.joca.2010.04.016) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Representative toluidine blue/fast green stained sections of cartilage from sheep with meniscectomy-induced OA, to demonstrate the features associated with the pathology scores for the different parameters outlined in Table IVA. A higher magnification image is included for cell cloning to demonstrate doublets, triplets and multiple cell nests (clusters). Osteoarthritis and Cartilage 2010 18, S80-S92DOI: (10.1016/j.joca.2010.04.016) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 6 Representative H&E stained sections of synovium from sheep with meniscectomy-induced OA to demonstrate the features associated with the pathology scores for the different parameters outlined in Table VA. The scores for intimal hyperplasia, lymphocytic/plasmacytic cellular infiltrate, sub-intimal fibrosis and vascularity are shown below each image and a magnified region showing detail of the synovial lining and sub-intima is shown in the bottom right of each section. Osteoarthritis and Cartilage 2010 18, S80-S92DOI: (10.1016/j.joca.2010.04.016) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions