Randomized, multicenter, double-blind, placebo-controlled trial to evaluate the efficacy and safety of synthetic conjugated estrogens B for the treatment.

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Presentation transcript:

Randomized, multicenter, double-blind, placebo-controlled trial to evaluate the efficacy and safety of synthetic conjugated estrogens B for the treatment of vulvovaginal atrophy in healthy postmenopausal women  James A. Simon, M.D., Kathleen Z. Reape, M.D., Steve Wininger, M.D., Howard Hait, M.S.  Fertility and Sterility  Volume 90, Issue 4, Pages 1132-1138 (October 2008) DOI: 10.1016/j.fertnstert.2007.07.1359 Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Disposition of patients and analysis. ∗The modified intent-to-treat (MITT) cohort served as the primary analysis cohort for all inferences regarding efficacy in this study. PPC = per-protocol completers; ITT = intent-to-treat. Fertility and Sterility 2008 90, 1132-1138DOI: (10.1016/j.fertnstert.2007.07.1359) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Changes in mean VMI, from baseline to end of treatment. Fertility and Sterility 2008 90, 1132-1138DOI: (10.1016/j.fertnstert.2007.07.1359) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Changes in mean severity of MBS, from baseline to end of treatment. Fertility and Sterility 2008 90, 1132-1138DOI: (10.1016/j.fertnstert.2007.07.1359) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

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