A Radical Role for TOR in Longevity Dudley W. Lamming, David M. Sabatini  Cell Metabolism  Volume 13, Issue 6, Pages 617-618 (June 2011) DOI: 10.1016/j.cmet.2011.05.006 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Rapamycin Promotes Yeast Chronological Life Span Rapamycin treatment of a yeast culture (top) during the logarithmic growth phase increases mitochondrial respiration and the generation of reactive oxygen species, resulting in the induction of cellular defense mechanisms that protect the yeast and will preserve viability during stationary phase. In contrast, an untreated yeast culture (bottom) experiences less oxidative stress during logarithmic growth and is unprepared for the harsh environment of stationary phase. Figure by Tom DiCesare, Whitehead Institute. Cell Metabolism 2011 13, 617-618DOI: (10.1016/j.cmet.2011.05.006) Copyright © 2011 Elsevier Inc. Terms and Conditions