Clinical and preclinical perspectives on Chemotherapy-Induced Peripheral Neuropathy (CIPN): a narrative review S.J.L. Flatters, P.M. Dougherty, L.A.

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Clinical and preclinical perspectives on Chemotherapy-Induced Peripheral Neuropathy (CIPN): a narrative review S.J.L. Flatters, P.M. Dougherty, L.A. Colvin British Journal of Anaesthesia Volume 119, Issue 4, Pages 737-749 (October 2017) DOI: 10.1093/bja/aex229 Copyright © 2017 The Author(s) Terms and Conditions

Fig 1 Summary of the pathophysiological events contributing to chemotherapy-induced peripheral neuropathy (CIPN) as highlighted in this review. The most common agents provoking CIPN are shown in the bubble in A and the sites of action for these compounds are indicated by the arrows. The structures are also labeled in A while in B the changes occurring in these structures with CIPN are summarized. Reproduced with permission from Boyette-Davis JA, Walters ET, Dougherty PM, Mechanisms involved in the development of chemotherapy induced peripheral neuropathy. Pain Manag. 5 (4): 285-296, 2015. British Journal of Anaesthesia 2017 119, 737-749DOI: (10.1093/bja/aex229) Copyright © 2017 The Author(s) Terms and Conditions