Advances in basic and clinical immunology in 2011 Javier Chinen, MD, PhD, William T. Shearer, MD, PhD Journal of Allergy and Clinical Immunology Volume 129, Issue 2, Pages 342-348 (February 2012) DOI: 10.1016/j.jaci.2011.11.047 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions
Fig 1 Development of induced pluripotent stem cells (iPSCs) and differentiation into different cell lineages. Fibroblasts are obtained from a skin biopsy specimen and reprogrammed into iPSCs by expressing 4 genes (OCT4, KLF4, SOX2, and cMYC) introduced by the STEMCCA lentiviral vector. Different cell lineages can be differentiated in vitro by using specific culture conditions.59 CNS, Central nervous system; GI, gastrointestinal; HSC, hematopoietic stem cell; LTR, long terminal repeat. Journal of Allergy and Clinical Immunology 2012 129, 342-348DOI: (10.1016/j.jaci.2011.11.047) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions