Volume 11, Issue 3, Pages (September 2012)

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Volume 11, Issue 3, Pages 287-288 (September 2012) Relief with Rapamycin: mTOR Inhibition Protects against Radiation-Induced Mucositis Toren Finkel Cell Stem Cell Volume 11, Issue 3, Pages 287-288 (September 2012) DOI: 10.1016/j.stem.2012.08.003 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 The Role of mTOR in Radiation-Induced Mucositis Irradiation of epithelial stem cells leads to mTOR activation. Inhibiting this activation with rapamycin treatment reduces the levels of ROS, inflammatory cytokine production, and overall DNA damage, and thereby prevents radiation-induced senescence. Rapamycin may also protect against the premature differentiation or apoptosis of stem and progenitor cells. These protective effects combine to prevent the appearance of clinically debilitating side-effects such as mucositis. Cell Stem Cell 2012 11, 287-288DOI: (10.1016/j.stem.2012.08.003) Copyright © 2012 Elsevier Inc. Terms and Conditions