Genome-wide association study of lung function decline in adults with and without asthma Medea Imboden, PhD, Emmanuelle Bouzigon, MD, PhD, Ivan Curjuric,

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Genome-wide association study of lung function decline in adults with and without asthma Medea Imboden, PhD, Emmanuelle Bouzigon, MD, PhD, Ivan Curjuric, MD, Adaikalavan Ramasamy, PhD, Ashish Kumar, MSc, Dana B. Hancock, PhD, Jemma B. Wilk, DSc, Judith M. Vonk, PhD, Gian A. Thun, MSc, Valerie Siroux, PhD, Rachel Nadif, PhD, Florent Monier, MSc, Juan R. Gonzalez, PhD, Matthias Wjst, MD, MD, Joachim Heinrich, PhD, Laura R. Loehr, MD, PhD, Nora Franceschini, MD, MPH, Kari E. North, PhD, Janine Altmüller, MD, Gerard H. Koppelman, MD, PhD, Stefano Guerra, MD, PhD, Florian Kronenberg, MD, Mark Lathrop, PhD, Miriam F. Moffatt, DPhil, George T. O’Connor, MD, MSc, David P. Strachan, MD, Dirkje S. Postma, MD, PhD, Stephanie J. London, MD, DrPH, Christian Schindler, PhD, Manolis Kogevinas, MD, Francine Kauffmann, MD, Debbie L. Jarvis, MD, Florence Demenais, MD, Nicole M. Probst-Hensch, PhD Journal of Allergy and Clinical Immunology Volume 129, Issue 5, Pages 1218-1228 (May 2012) DOI: 10.1016/j.jaci.2012.01.074 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Manhattan plots of association results for lung function decline. A, FEV1 decrease in nonasthmatic participants. B, FEV1 decrease in asthmatic participants. C, FEV1/FVC ratio decrease in nonasthmatic participants. D, FEV1/FVC ratio decrease in asthmatic participants. Journal of Allergy and Clinical Immunology 2012 129, 1218-1228DOI: (10.1016/j.jaci.2012.01.074) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Association of the DLEU7 locus with decrease in FEV1 in nonasthmatic participants. A, Regional association plot, discovery phase. B, Forest plot for rs9316500. A, Chromosome position (National Center for Biotechnology Information build 36.3) and recombination rate (hg18 build). The sentinel SNP is represented as a diamond and r2 value for SNPs to the sentinel SNP (HapMap CEU phase II). B, The size of the square of each study reflects the contributing weight to the meta-analysis. Details are shown in Table E11 in this article’s Online Repository at www.jacionline.org. Journal of Allergy and Clinical Immunology 2012 129, 1218-1228DOI: (10.1016/j.jaci.2012.01.074) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions