Kevin O’Brien, Nadeem Hussain, Bradley A. Warady, David E

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Presentation transcript:

Nodular Regenerative Hyperplasia and Severe Portal Hypertension in Cystinosis Kevin O’Brien, Nadeem Hussain, Bradley A. Warady, David E. Kleiner, Robert Kleta, Isa Bernardini, Theo Heller, William A. Gahl Clinical Gastroenterology and Hepatology Volume 4, Issue 3, Pages 387-394 (March 2006) DOI: 10.1016/j.cgh.2005.12.013 Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

Figure 1 Representative photomicrographs of the second liver biopsy specimen from patient 1. (A) Routine staining shows unremarkable hepatic parenchyma with only a suggestion of nodularity (H&E, original magnification, 10×). (B) Mild portal fibrotic expansion is apparent in most of the portal areas. The portal vein is present (Masson trichrome, original magnification, 10×). (C) Delicate perisinusoidal fibrosis is present around the central veins (Masson trichrome, original magnification, 40×). (D) The reticulin stain shows the nodularity of the hepatic parenchyma with alternating zones of compression and expansion of liver cell plates (reticulin, original magnification, 10×). Clinical Gastroenterology and Hepatology 2006 4, 387-394DOI: (10.1016/j.cgh.2005.12.013) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

Figure 2 Representative photomicrographs of the liver biopsy specimen from patient 2. (A) Clusters of vacuolated macrophages were seen in sinuses adjacent to central veins. There also is mild sinusoidal dilatation adjacent to the sinuses that are filled with macrophages (H&E, original magnification, 20×). (B) On reticulin stain there were some areas that showed widened liver cell plates, with 2 or 3 hepatocytes between layers of reticulin (reticulin, original magnification, 40×). (C) Elsewhere, particularly in the vicinity of central veins, there was compression of liver cell plates with accentuation of reticulin (reticulin, original magnification, 40×). Clinical Gastroenterology and Hepatology 2006 4, 387-394DOI: (10.1016/j.cgh.2005.12.013) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions