SIRT6 Puts Cancer Metabolism in the Driver’s Seat

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SIRT6 Puts Cancer Metabolism in the Driver’s Seat Costas A. Lyssiotis, Lewis C. Cantley Cell Volume 151, Issue 6, Pages 1155-1156 (December 2012) DOI: 10.1016/j.cell.2012.11.020 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Loss of SIRT6-Mediated Suppression of Cancer Metabolism Promotes Tumorigenesis (A) The deacetylase SIRT6 acts as a corepressor of HIF-1α- and MYC-dependent cancer metabolism but does not globally repress HIF-1α or MYC transcription. (B) SIRT6 inhibits aerobic glycolysis, anabolic glutamine metabolism, and ribosome biogenesis. Together, activation of these metabolic pathways promotes tumorigenesis and tumor growth. Inhibition of aerobic glycolysis by knockdown of PDK1 using short hairpin RNA (shPDK1) or pharmacological inhibition with dichloroacetate (DCA) blocks the tumorigenic activity of SIRT6 loss. Cell 2012 151, 1155-1156DOI: (10.1016/j.cell.2012.11.020) Copyright © 2012 Elsevier Inc. Terms and Conditions