Volume 15, Issue 1, Pages (January 2012)

Slides:



Advertisements
Similar presentations
SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration Amit R. Reddi, Valeria C. Culotta Cell Volume 152, Issue 1, Pages (January.
Advertisements

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.
The RAG Recombinase Dictates Functional Heterogeneity and Cellular Fitness in Natural Killer Cells Jenny M. Karo, David G. Schatz, Joseph C. Sun Cell Volume.
The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity Jenni Durieux, Suzanne Wolff, Andrew Dillin Cell Volume 144, Issue 1, Pages.
What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell
Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.
Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni
Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet
Common Sense about Taste: From Mammals to Insects David A. Yarmolinsky, Charles S. Zuker, Nicholas J.P. Ryba Cell Volume 139, Issue 2, Pages (October.
Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase Simon A. Hawley, David A. Pan, Kirsty J.
Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell
Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis Wing-Hang Tong, Tracey A. Rouault Cell.
PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors Joan Sanchez-Gurmaches, Chien-Min.
Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem
Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell
ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics Carlos L. Arteaga, Jeffrey A. Engelman Cancer Cell Volume.
IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.
Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.
The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.
Healthy clocks, healthy body, healthy mind Akhilesh B. Reddy, John S. O’Neill Trends in Cell Biology Volume 20, Issue 1, Pages (January 2010) DOI:
A View to a Kill: The Bacterial Type VI Secretion System Brian T. Ho, Tao G. Dong, John J. Mekalanos Cell Host & Microbe Volume 15, Issue 1, Pages 9-21.
Lipin-1 Regulates Autophagy Clearance and Intersects with Statin Drug Effects in Skeletal Muscle Peixiang Zhang, M. Anthony Verity, Karen Reue Cell Metabolism.
CDK Inhibitors: Cell Cycle Regulators and Beyond Arnaud Besson, Steven F. Dowdy, James M. Roberts Developmental Cell Volume 14, Issue 2, Pages
Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:
Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.
Low-Dose Aspirin in Patients with Stable Cardiovascular Disease: A Meta-analysis Jeffrey S. Berger, MD, MS, David L. Brown, MD, Richard C. Becker, MD The.
Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages (March 2005) DOI: /j.devcel
Quantitative Single-Cell Approaches to Stem Cell Research Martin Etzrodt, Max Endele, Timm Schroeder Cell Stem Cell Volume 15, Issue 5, Pages (November.
Oxygen Sensors at the Crossroad of Metabolism Julián Aragonés, Peter Fraisl, Myriam Baes, Peter Carmeliet Cell Metabolism Volume 9, Issue 1, Pages
Volume 14, Issue 2, Pages (August 2011)
Jochen G. Schneider, Joseph H. Nadeau  Cell Metabolism 
Metabolism by Remote Control
“Corination” of the proANP converting enzyme
Boosting Bacterial Metabolism to Combat Antibiotic Resistance
Pancreatic β cells: Responding to the matrix
Volume 13, Issue 1, Pages 5-6 (January 2011)
Serotonin and the Orchestration of Energy Balance
Volume 24, Issue 3, Pages (September 2016)
Once Blind, Now We See GLP-1 Molecular Action
Getting to the heart of COX-2 inhibition
Communication in Drug Development: “Translating” Scientific Discovery
Assessment of Feeding Behavior in Laboratory Mice
Come on BAIBA Light My Fire
Is Predisposition to NAFLD and Obesity Communicable?
Getting to the heart of COX-2 inhibition
Organoid Center Strategies for Accelerating Clinical Translation
Volume 13, Issue 1, Pages 5-6 (January 2011)
Volume 26, Issue 1, Pages 6-7 (July 2017)
Treating Obesity? It's in the Bag!
IL-6 Muscles In on the Gut and Pancreas to Enhance Insulin Secretion
Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes
Volume 152, Issue 1, (January 2013)
Beyond Energy Homeostasis: the Expanding Role of AMP-Activated Protein Kinase in Regulating Metabolism  David Carling, Benoit Viollet  Cell Metabolism 
Modifying Mitochondrial tRNAs: Delivering What the Cell Needs
Do Cancer Cells Care If Their Host Is Hungry?
Exercise Controls Non-Coding RNAs
Volume 14, Issue 2, Pages (August 2011)
Oxytocin: The Neuropeptide of Love Reveals Some of Its Secrets
Chapter 64 - Renal Calcium Metabolism
Chapter 29 - Stem Cells and Generation of New Cells in the
Hap1 and GABA: Thinking about food intake
Macrophage Metabolism Shapes Angiogenesis in Tumors
Volume 24, Issue 1, Pages 7-8 (July 2016)
Stem Cells and Oxidants: Too Little of a Bad Thing
Of Mice and Men: Not ExAKTly the Same?
Many Roads Lead to the Lipid Droplet
Tipping the Energy Balance toward Longevity
David Hubel and Torsten Wiesel
AMPK and p53 help cells through lean times
Volume 148, Issue 1, (January 2012)
Presentation transcript:

Volume 15, Issue 1, Pages 19-24 (January 2012) Metabolic Disease Drug Discovery— “Hitting the Target” Is Easier Said Than Done  David E. Moller  Cell Metabolism  Volume 15, Issue 1, Pages 19-24 (January 2012) DOI: 10.1016/j.cmet.2011.10.012 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Roadmap for Common Practices in Current Drug Discovery/Development Industry-based efforts focusing on cardiometabolic disease have largely mirrored the trends and approaches noted in this generic R&D paradigm. Cell Metabolism 2012 15, 19-24DOI: (10.1016/j.cmet.2011.10.012) Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 2 Abbreviated Timeline of the Discovery and Development of GLP-1 Receptor Agonists and DPP-4 Inhibitors Cell Metabolism 2012 15, 19-24DOI: (10.1016/j.cmet.2011.10.012) Copyright © 2012 Elsevier Inc. Terms and Conditions