Volume 140, Issue 2, Pages 488-496.e4 (February 2011) Prognostic Importance of the Cause of Renal Failure in Patients With Cirrhosis  Marta Martín–Llahí, Mónica Guevara, Aldo Torre, Claudia Fagundes, Tea Restuccia, Rosa Gilabert, Elsa Solá, Gustavo Pereira, Marcella Marinelli, Marco Pavesi, Javier Fernández, Juan Rodés, Vicente Arroyo, Pere Ginès  Gastroenterology  Volume 140, Issue 2, Pages 488-496.e4 (February 2011) DOI: 10.1053/j.gastro.2010.07.043 Copyright © 2011 AGA Institute Terms and Conditions

Figure 1 Three-month probability of survival of patients with cirrhosis and renal failure categorized in 4 different groups according to the cause of renal failure: renal failure due to parenchymal nephropathy, hypovolemia-associated renal failure, infection-associated renal failure, and HRS (P < .0005). HRS was defined according to the classical diagnostic criteria (Arroyo et al8). Figures under the curves are patients at risk at different time points. Gastroenterology 2011 140, 488-496.e4DOI: (10.1053/j.gastro.2010.07.043) Copyright © 2011 AGA Institute Terms and Conditions

Figure 2 Three-month probability of survival of patients with cirrhosis and renal failure categorized in 3 different groups according to the cause of renal failure: renal failure due to parenchymal nephropathy, hypovolemia-associated renal failure, and HRS (P < .0005). HRS was defined according to the new diagnostic criteria (Salerno et al9), which include patients with HRS diagnosed with the classical criteria (Arroyo et al8) plus patients with active infections but without septic shock. Figures under the curves are patients at risk at different time points. Gastroenterology 2011 140, 488-496.e4DOI: (10.1053/j.gastro.2010.07.043) Copyright © 2011 AGA Institute Terms and Conditions

Figure 3 Plots of relationship of MELD score and 3-month probability of death in the different categories of renal failure. (Left graph) MELD scores according to 4 categories of renal failure as shown in Supplementary Table 4 (patients without hepatic encephalopathy). (Right graph) MELD scores according to 3 categories of renal failure, as shown in Supplementary Table 6. HRS, hepatorenal syndrome. *Hepatorenal syndrome defined according to the most recent diagnostic criteria.9 Gastroenterology 2011 140, 488-496.e4DOI: (10.1053/j.gastro.2010.07.043) Copyright © 2011 AGA Institute Terms and Conditions

Supplementary Figure 1 Three-month probability of survival of patients with cirrhosis and renal failure due to mixed causes of renal failure (combination of infection, hypovolemia, or parenchymal nephropathy; 45 patients), drug-induced (42 patients), and miscellaneous (12 patients) conditions. Figures under the curves are patients at risk at different time points. Gastroenterology 2011 140, 488-496.e4DOI: (10.1053/j.gastro.2010.07.043) Copyright © 2011 AGA Institute Terms and Conditions

Supplementary Figure 2 Disposition of patients in the study according to the cause of renal failure. See Supplementary Materials and Methods. Gastroenterology 2011 140, 488-496.e4DOI: (10.1053/j.gastro.2010.07.043) Copyright © 2011 AGA Institute Terms and Conditions

Supplementary Figure 3 Three-month probability of survival of 285 patients with an available serum creatinine concentration within 3 months before admission divided into 3 groups: chronic renal failure, chronic renal failure with superimposed acute renal impairment, and acute renal failure. Figures under the curves are patients at risk at different time points. Gastroenterology 2011 140, 488-496.e4DOI: (10.1053/j.gastro.2010.07.043) Copyright © 2011 AGA Institute Terms and Conditions