Volume 56, Issue 5, Pages (November 1999)

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Presentation transcript:

Volume 56, Issue 5, Pages 1967-1979 (November 1999) Why do we reject a graft? Role of indirect allorecognition in graft rejection Mohamed H. Sayegh Kidney International Volume 56, Issue 5, Pages 1967-1979 (November 1999) DOI: 10.1046/j.1523-1755.1999.00751.x Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 1 Graft morphology. (A) This photograph illustrates extensive tubular atrophy. Tubular basement membranes are thickened and the interstitium is expanded by connective tissue. (B) Arteries reveal extensive accumulation of connective tissue in the media and in the expanded intima, resulting in substantial narrowing of the lumen. (C) Glomeruli also reveal obsolescence of the capillary that results in global or segmental glomerulosclerosis. The collapsed capillaries often entrap hyaline material, as depicted in this glomerulus with segmental sclerosis (PAS stain, ×400; courtesy of Dr. H.G. Rennke, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA). Kidney International 1999 56, 1967-1979DOI: (10.1046/j.1523-1755.1999.00751.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 2 Mechanisms of allorecognition and graft rejection.. Adapted from19 with permission. Kidney International 1999 56, 1967-1979DOI: (10.1046/j.1523-1755.1999.00751.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 3 Contribution of indirect allorecognition to graft rejection: A working hypothesis. Adapted from48 with permission. Kidney International 1999 56, 1967-1979DOI: (10.1046/j.1523-1755.1999.00751.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 4 Role of indirect allorecognition in chronic allograft rejection: A working hypothesis. Adapted from67 with permission. Kidney International 1999 56, 1967-1979DOI: (10.1046/j.1523-1755.1999.00751.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Kidney International 1999 56, 1967-1979DOI: (10. 1046/j. 1523-1755 Kidney International 1999 56, 1967-1979DOI: (10.1046/j.1523-1755.1999.00751.x) Copyright © 1999 International Society of Nephrology Terms and Conditions