Rewarming Rate During Cardiopulmonary Bypass Is Associated With Release of Glial Fibrillary Acidic Protein Daijiro Hori, MD, Allen D. Everett, MD, Jennifer.

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Rewarming Rate During Cardiopulmonary Bypass Is Associated With Release of Glial Fibrillary Acidic Protein Daijiro Hori, MD, Allen D. Everett, MD, Jennifer K. Lee, MD, Masahiro Ono, MD, PhD, Charles H. Brown, MD, Ashish S. Shah, MD, Kaushik Mandal, MD, Joel E. Price, MD, MPH, Laeben C. Lester, MD, Charles W. Hogue, MD The Annals of Thoracic Surgery Volume 100, Issue 4, Pages 1353-1358 (October 2015) DOI: 10.1016/j.athoracsur.2015.04.006 Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Box and whisker plots showing the changes in plasma glial fibrillary acidic protein (GFAP) levels from the measurements obtained before and after cardiopulmonary bypass (CPB). The horizontal line in the shaded box represents the median value, and the shaded box represents the interquartile range. The error bars below and above the shaded area represent ±1.5× the interquartile range; points beyond the error bars are outliers. The Annals of Thoracic Surgery 2015 100, 1353-1358DOI: (10.1016/j.athoracsur.2015.04.006) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Scatter plot of glial fibrillary acidic protein (GFAP) with (A) rewarming rate and (B) maximal temperature. The dashed lines represent 95% confidence intervals for the fitted lines. There was a significant correlation between log GFAP and rewarming rate (r = 0.26; 95% confidence interval, 0.11 to 0.41; p = 0.001). There was no significant correlation between log GFAP and maximal temperature (r = 0.02; 95% confidence interval, −0.14 to 0.18; p = 0.77). The Annals of Thoracic Surgery 2015 100, 1353-1358DOI: (10.1016/j.athoracsur.2015.04.006) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 (A) Bar graph and (B) box and whisker plot showing the relationship between rewarming rate (p = 0.048) and plasma glial fibrillary acidic protein (GFAP) levels for patients with and without postoperative stroke. For the latter, the horizontal line in the shaded box for the box and whisker plot represents the median value, and the shaded box represents the interquartile range. The error bars below and above the shaded area represent ±1.5× the interquartile range; points beyond the error bar are outliers. The Annals of Thoracic Surgery 2015 100, 1353-1358DOI: (10.1016/j.athoracsur.2015.04.006) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions