Volume 74, Issue 4, Pages (October 2018)

Slides:

Advertisements

Similar presentations

Volume 69, Issue 6, Pages (June 2016)

Advertisements

Molecular Dissection of Complete Response to Receptor Tyrosine Kinase Inhibition in Type II Papillary Renal Cell Carcinoma Matti Annala, Lucia Nappi,

Volume 63, Issue 2, Pages (February 2013)

Inflammatory Protein Serum Amyloid A1 Marks a Subset of Conventional Renal Cell Carcinomas with Fatal Outcome Claudia Paret, Zorica Schön, Adrianna Szponar,

Triple-Negative Breast Cancer

Primary Urethral Clear-Cell Adenocarcinoma

Long Noncoding RNA in Prostate, Bladder, and Kidney Cancer

Volume 6, Issue 4, Pages (April 2004)

Volume 52, Issue 1, Pages (July 2007)

Volume 71, Issue 2, Pages (February 2017)

Volume 49, Issue 1, Pages (January 2006)

The Functional Impact of Alternative Splicing in Cancer

Volume 53, Issue 5, Pages (May 2008)

Hendrikus J. Dubbink, Peggy N. Atmodimedjo, Ronald van Marion, Niels M

Highly heterogeneous genomic landscape of uterine leiomyomas by whole exome sequencing and genome-wide arrays Svetlana A. Yatsenko, M.D., Priya Mittal,

Volume 49, Issue 6, Pages (June 2006)

Volume 69, Issue 6, Pages (June 2016)

Neeraj Agarwal, Guru Sonpavde, Cora N. Sternberg European Urology

Volume 72, Issue 4, Pages (October 2017)

Adeno-associated Virus Serotype Vectors Efficiently Transduce Normal Prostate Tissue and Prostate Cancer Cells Jianzhong Ai, Dan Wang, Qiang Wei, Hong.

Volume 54, Issue 4, Pages (October 2008)

Volume 61, Issue 2, Pages (February 2012)

Volume 2, Issue 4, Pages (April 2008)

On the Origin of Syn- and Metachronous Urothelial Carcinomas

Volume 74, Issue 5, Pages (November 2018)

Volume 117, Issue 6, Pages (December 1999)

Shaheen Alanee, Kasmintan Schrader, Kenneth Offit European Urology

International Society of Urological Pathology Grading and Other Prognostic Factors for Renal Neoplasia Brett Delahunt, John R. Srigley, Lars Egevad,

Volume 50, Issue 3, Pages (September 2006)

Array-CGH Reveals Recurrent Genomic Changes in Merkel Cell Carcinoma Including Amplification of L-Myc Kelly G. Paulson, Bianca D. Lemos, Bin Feng, Natalia.

Mark A. Rubin, Gabriele Girelli, Francesca Demichelis European Urology

Volume 72, Issue 4, Pages (October 2017)

Mutational burden of somatic, protein-altering mutations per subject from WES for patients with advanced colon cancer who participated in PD-1 blockade.

Volume 11, Issue 2, Pages (August 2012)

Diagnostic Value of Albumin Gene Expression in Liver Tumors: Case Report and Review of the Literature S. Vincent Rajkumar, M.D., Ronald L. Richardson,

A Tumor Sorting Protocol that Enables Enrichment of Pancreatic Adenocarcinoma Cells and Facilitation of Genetic Analyses Zachary S. Boyd, Rajiv Raja,

Basic Research in Kidney Cancer

Volume 68, Issue 1, Pages (July 2015)

Notch Activation as a Driver of Osteogenic Sarcoma

Volume 122, Issue 3, Pages (March 2002)

Volume 29, Issue 5, Pages (May 2016)

Volume 69, Issue 5, Pages (May 2016)

Molecular Aspects of Melanocytic Dysplastic Nevi

Enhanced expression of glucose transporter-1 in vascular smooth muscle cells via the Akt/tuberous sclerosis complex subunit 2 (TSC2)/mammalian target.

The Functional Impact of Alternative Splicing in Cancer

Volume 63, Issue 2, Pages (February 2013)

Whole genome characterization of hepatitis B virus quasispecies with massively parallel pyrosequencing F. Li, D. Zhang, Y. Li, D. Jiang, S. Luo, N. Du,

Volume 4, Issue 6, Pages (September 2013)

Shyam S. Jayaraman, David J. Rayhan, Salar Hazany, Michael S. Kolodney

Volume 16, Issue 3, Pages (March 2015)

Volume 24, Issue 7, Pages (August 2018)

Volume 56, Issue 4, Pages (October 1999)

Volume 9, Issue 4, Pages (November 2014)

Volume 13, Issue 4, Pages (April 2013)

Volume 29, Issue 5, Pages (May 2016)

Giulia Quattrocolo, Gord Fishell, Timothy J. Petros Cell Reports

Catherine C. Roberts, M. D. , Thomas V. Colby, M. D. , Kenneth P

Targeted Deletion of an Entire Chromosome Using CRISPR/Cas9

Single Base Instability Is Promoted in Vulvar Lichen Sclerosus

Volume 26, Issue 6, Pages (June 2018)

Volume 8, Issue 1, Pages (July 2014)

Highly heterogeneous genomic landscape of uterine leiomyomas by whole exome sequencing and genome-wide arrays Svetlana A. Yatsenko, M.D., Priya Mittal,

Giulia Quattrocolo, Gord Fishell, Timothy J. Petros Cell Reports

Update on the Medical Treatment of Metastatic Renal Cell Carcinoma

The 3D Genome in Transcriptional Regulation and Pluripotency

Volume 19, Issue 11, Pages (June 2017)

Volume 76, Issue 4, Pages (October 2019)

Mutational Analysis of Ionizing Radiation Induced Neoplasms

Single nucleotide polymorphism array analysis can distinguish different genetic mechanisms that lead to loss of heterozygosity (LOH). Single nucleotide.

Volume 150, Issue 1, Pages (July 2012)

Presentation transcript:

Volume 74, Issue 4, Pages 483-486 (October 2018) Somatic Bi-allelic Loss of TSC Genes in Eosinophilic Solid and Cystic Renal Cell Carcinoma Rohit Mehra, Pankaj Vats, Xuhong Cao, Fengyun Su, Nicole D. Lee, Robert Lonigro, Kumpati Premkumar, Kiril Trpkov, Jesse K. McKenney, Saravana M. Dhanasekaran, Arul M. Chinnaiyan European Urology Volume 74, Issue 4, Pages 483-486 (October 2018) DOI: 10.1016/j.eururo.2018.06.007 Copyright © 2018 European Association of Urology Terms and Conditions

Fig. 1 Somatic bi-allelic loss of tuberous sclerosis complex (TSC) genes in eosinophilic solid and cystic renal cell carcinoma (ESC RCC). (A) Low (top) and high (middle) magnification of the histology images of a representative ESC RCC case with solid and cystic growth pattern and cells with abundant eosinophilic cytoplasm; high (bottom) magnification of a TSC RCC case with similar morphology to ESC RCC. Scale bars low: 1mm and high: 100μm. (B) Schematic representation of TSC1 protein domains with the observed mutational events in ESC RCC (top) and copy number loss of heterozygosity (LOH) plots for chromosomes 8, 9, and 10 (bottom). TSC1 is located on chromosome 9 in the human genome. (C) Schematic representation of TSC2 protein functional domains with the observed mutational events in ESC RCC (top) and copy number LOH plots for chromosomes 15, 16, and 17 (bottom). TSC2 is located on chromosome 16 in the human genome. Deleterious somatic mutations, including frameshift indels (orange), nonsense (deep red), and splice site (blue) events in TSC genes are depicted. Copy number plots green: LOH; red: gain; black: diploid. (D) Table summarizes the mutually exclusive TSC gene aberrations in ESC RCC samples. (E) Flow chart indicates the type of TSC aberrations that characterizes and distinguishes TSC RCC from ESC. European Urology 2018 74, 483-486DOI: (10.1016/j.eururo.2018.06.007) Copyright © 2018 European Association of Urology Terms and Conditions

Fig. 2 Bi-allelic loss of tuberous sclerosis complex genes activates mammalian target of rapamycin pathway in eosinophilic solid and cystic renal cell carcinoma (ESC RCC). (A) Hematoxylin and eosin stained section from ESC RCC showing characteristic morphological features (red star) and background benign renal parenchyma (green star). Scale bar: 200μm. (B) Tumor cells diffusely and moderately express phospho-4E-BP1 (red star) with negative expression in the background renal parenchyma (green star). Scale bar: 200μm. (C) Tumor cells diffusely and strongly express phospho-S6 Rib P D68.F8 (red star) with weak expression in certain cell types in the background renal parenchyma (green star). Scale bar: 200μm. (D) Tumor cells diffusely and strongly express phospho-S6 Rib P D57.2.2E (red star) with weak to moderate expression in certain cell types within the background renal parenchyma (green star). Scale bar: 200μm. European Urology 2018 74, 483-486DOI: (10.1016/j.eururo.2018.06.007) Copyright © 2018 European Association of Urology Terms and Conditions