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A presentation to: Meeting name Date Surgical interventions for primary congenital glaucoma Deepta Ghate, Xue Wang Issue 1, 2015 A presentation to: Meeting name Date

Table of Contents 01 Background 02 Types of studies 03 Key results 04 Tables (Risk of Bias/Forest Plots) 05 Conclusions 06 Acknowledgements

01: Background Primary congenital glaucoma (PCG) appears in the first few years of a child’s life There are several different surgical techniques used to treat PCG OBJECTIVE: To compare the effectiveness and safety of different surgical techniques for PCG

02: Types of studies Participants 6 RCTs; 102 eyes of 61 children Interventions Trabeculectomy versus goniotomy Trabeculectomy-trabeculotomy + Mitomycin C versus Trabeculectomy-trabeculotomy +mitomycin C + deep sclerectomy Combined trabeculectomy-trabeculotomy versus trabeculectomy

02: Types of studies Interventions (continued) One goniotomy versus two goniotomies Trabeculotomy versus viscocanalostomy Surgical goniotomy versus neodymium-YAG laser goniotomy

03: Key results “No two trials compared the same pair of surgical interventions, so we did not perform any meta-analysis.” “For IOP change and surgical success (defined by IOP achieved), none of the trials reported a difference between pairs of surgical techniques” “Adverse events, such as choroidal detachment, shallow anterior chamber and hyphema, were reported from four trials.”

04: Tables

05: Conclusions “These trials were neither designed nor reported well overall.” “No conclusions could be drawn from the trials included in this review due to paucity of data.”

06: Acknowledgements Cochrane Eyes and Vision US Satellite, funded by the National Eye Institute, National Institutes of Health Cochrane Eyes and Vision Editorial Base, funded by the UK National Health Service Research and Development Programme Deepta Ghate, Xue Wang Review citation Ghate D, Wang X. Surgical interventions for primary congenital glaucoma. Cochrane Database of Systematic Reviews 2015, Issue 1. Art. No.: CD008213. DOI: 10.1002/14651858.CD008213.pub2