Volume 118, Issue 1, Pages 7-13 (January 2000)

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Volume 118, Issue 1, Pages 7-13 (January 2000) Control of transient lower esophageal sphincter relaxations and reflux by the GABAB agonist baclofen in normal subjects Ilmars Lidums, Anders Lehmann, Helen Checklin, John Dent, Richard H. Holloway Gastroenterology Volume 118, Issue 1, Pages 7-13 (January 2000) DOI: 10.1016/S0016-5085(00)70408-2 Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 1 Protocol for each study day. 1°P, primary peristalsis; 2°P, secondary peristalsis; VAS, visual analogue scale. Gastroenterology 2000 118, 7-13DOI: (10.1016/S0016-5085(00)70408-2) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 2 fig 2. Effect of baclofen on basal LES pressure. Data are expressed as mean ± SEM for each postprandial hour and for the whole 3-hour postprandial period. n.s., not significant. Gastroenterology 2000 118, 7-13DOI: (10.1016/S0016-5085(00)70408-2) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 3 Effect of baclofen on the rate of transient LES relaxations. Data are expressed as median (interquartile range) for each postprandial hour and for the whole 3-hour postprandial period. Gastroenterology 2000 118, 7-13DOI: (10.1016/S0016-5085(00)70408-2) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 4 Effect of baclofen on the rate of reflux episodes. Data are expressed as median (interquartile range) for each postprandial hour and for the whole 3-hour postprandial period. n.s., not significant. Gastroenterology 2000 118, 7-13DOI: (10.1016/S0016-5085(00)70408-2) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 5 (A) Plasma levels of baclofen after a single oral dose of 40 mg. (B) Effect of baclofen on plasma levels of growth hormone. Data are mean ± SEM. Gastroenterology 2000 118, 7-13DOI: (10.1016/S0016-5085(00)70408-2) Copyright © 2000 American Gastroenterological Association Terms and Conditions